Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XIAP | P98170 | 3/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.41 |
| ▸ | CDK2 | P24941 | 3/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.41 |
| ▸ | GLS | O94925 | 5/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ELOVL1 | Q9BW60 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5767301 | 0.89 | MEN1 (0.41) | XIAPCCNA2CDK2CCNA1GLS | |
| SCHEMBL3157338 | 0.85 | GPR88 (0.38) | XIAPCCNA2CDK2CCNA1GLS | |
| SCHEMBL3157695 | 0.84 | XIAP (0.49) | XIAPCCNA2CDK2CCNA1GLS | |
| Formic Acid SCHEMBL4804385 | 0.81 | XIAP (0.47) | XIAPCCNA2CDK2CCNA1GLS | |
| SCHEMBL4804382 | 0.81 | XIAP (0.45) | XIAPCCNA2CDK2CCNA1GLS | |
| SCHEMBL4801228 | 0.81 | XIAP (0.45) | XIAPGLSPOLBALDH1A1LMNA | |
| SCHEMBL3173967 | 0.78 | RAB9A (0.64) | GLSALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL3162800 | 0.76 | XIAP (0.45) | XIAPCCNA2CDK2CCNA1GLS | |
| SCHEMBL6210140 | 0.76 | TSHR (0.36) | XIAPPOLBALDH1A1LMNAMEN1 | |
| SCHEMBL3166052 | 0.76 | ALOX5 (0.49) | GLSPOLBALDH1A1LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716128-B1 | SUBSTITUTED 4,5,6,7-TETRAHYDRO-BENZOTHIAZOL-2-YLAMINE COMPOUNDS | GRUENENTHAL GMBH (DE) | 2010-03-31 | — | — | EP | claimed |
| JP-2007522171-A | — | — | 2007-08-09 | — | — | JP | claimed |
| EP-1716128-A1 | SUBSTITUTED 4,5,6,7-TETRAHYDRO-BENZOTHIAZOL-2-YLAMINE COMPOUNDS | Grünenthal GmbH (DE) | 2006-11-02 | — | — | EP | claimed |
| WO-2005077924-A1 | SUBSTITUTED 4,5,6,7-TETRAHYDRO-BENZOTHIAZOL-2-YLAMINE COMPOUNDS | Grünenthal GmbH (DE) | 2005-08-25 | — | — | WO | claimed |
| EP-1716128-B1 | SUBSTITUTED 4,5,6,7-TETRAHYDRO-BENZOTHIAZOL-2-YLAMINE COMPOUNDS | GRUENENTHAL GMBH (DE) | 2010-03-31 | — | — | EP | disclosed |
| EP-1716128-A1 | SUBSTITUTED 4,5,6,7-TETRAHYDRO-BENZOTHIAZOL-2-YLAMINE COMPOUNDS | Grünenthal GmbH (DE) | 2006-11-02 | — | — | EP | disclosed |
| WO-2005077924-A1 | SUBSTITUTED 4,5,6,7-TETRAHYDRO-BENZOTHIAZOL-2-YLAMINE COMPOUNDS | Grünenthal GmbH (DE) | 2005-08-25 | — | — | WO | disclosed |