Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | ACACB | O00763 | 2/20 | 0.34 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.34 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TRPC6 | Q9Y210 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31722347 | 0.86 | HRH3 (0.59) | HRH3MAPTACACBACKR3NPC1 | |
| SCHEMBL30723925 | 0.78 | CHRNB2 (0.53) | HRH3MAPTCHRNB2CHRNB4CHRNA3 | |
| SCHEMBL27042090 | 0.77 | CHRNB2 (0.49) | CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL31607811 | 0.77 | TRPC6 (0.39) | HRH3CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL26641428 | 0.77 | TRPC6 (0.39) | HRH3CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL31607877 | 0.77 | MAPT (0.62) | HRH3MAPTCHRNB2CHRNB4CHRNA3 | |
| SCHEMBL26641388 | 0.77 | MAPT (0.62) | HRH3MAPTCHRNB2CHRNB4CHRNA3 | |
| Lithium Ion SCHEMBL20163088 | 0.76 | HDAC3 (0.49) | MAPTNPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL30963410 | 0.74 | CRBN (0.51) | HRH3 | |
| SCHEMBL31198943 | 0.73 | HRH3 (0.52) | HRH3MAPTACACBNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025228947-A1 | BIFUNCTIONAL COMPOUNDS CAPABLE OF INDUCING DEGRADATION OF POLO-LIKE KINASE1 | CROSSFIRE ONCOLOGY B.V. (NL) | 2025-11-06 | — | — | WO | disclosed |