SCHEMBL31729055

SCHEMBL31729055

CNCc1nn(C)c2cccc(Cl)c12

nearest known ligand 0.38

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ CCR4 P51679 4/20 0.38
▸ MAPK13 O15264 1/20 0.35
▸ EIF2AK2 P19525 1/20 0.35
▸ MAPK12 P53778 1/20 0.35
▸ MAPK11 Q15759 1/20 0.35
▸ MAPK14 Q16539 1/20 0.35
▸ TP53 P04637 1/20 0.35
▸ KCNA5 P22460 1/20 0.34
▸ MAPT P10636 2/20 0.34
▸ NPC1 O15118 1/20 0.34
▸ GAA P10253 1/20 0.34
▸ PDCD1 Q15116 2/20 0.33
▸ CD274 Q9NZQ7 2/20 0.33
▸ GPR84 Q9NQS5 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31728953 0.76 POLB (0.49) CCR4GAA
SCHEMBL30013679 0.75 CCR4 (0.41) CCR4MAPK13EIF2AK2MAPK12MAPK11
SCHEMBL2274030 0.73 KDM4E (0.42) CCR4GPR84
SCHEMBL13106161 0.73 NR3C1 (0.41) CCR4MAPK13EIF2AK2MAPK12MAPK11
SCHEMBL31728023 0.71 CCR4 (0.39) CCR4MAPK13EIF2AK2MAPK12MAPK11
SCHEMBL17984817 0.71 PSMB8 (0.40) CCR4MAPK13EIF2AK2MAPK12MAPK11
SCHEMBL1093107 0.70 GPR84 (0.42) TP53MAPTGPR84
SCHEMBL20430045 0.69 CCR4 (0.43) CCR4MAPK13EIF2AK2MAPK12MAPK11
SCHEMBL17057091 0.69 HTR3A (0.32) CCR4
SCHEMBL13673002 0.68 CCR4 (0.40) CCR4MAPK13EIF2AK2MAPK12MAPK11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025236004-A1 STAT6 INHIBITORS AND USES THEREOF KYMERA THERAPEUTICS, INC. (US) 2025-11-13 — — WO disclosed
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