SCHEMBL31738271

SCHEMBL31738271

NC(=O)n1ccnc1Cc1ccc(N)cc1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 0.39
ALDH1A1 P00352 1/20 0.39
TSHR P16473 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.38
CYP11B1 P15538 2/20 0.38
CYP11B2 P19099 2/20 0.38
CYP19A1 P11511 2/20 0.38
CYP17A1 P05093 2/20 0.38
PARP1 P09874 1/20 0.36
KMT2A Q03164 1/20 0.36
RXFP1 Q9HBX9 1/20 0.36
RAD52 P43351 1/20 0.35
FDPS P14324 1/20 0.35
HRH3 Q9Y5N1 1/20 0.32
CA12 O43570 1/20 0.32
CA1 P00915 1/20 0.32
CA2 P00918 1/20 0.32
CA9 Q16790 1/20 0.32
CA14 Q9ULX7 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29234165 0.82 PARP1 (0.43) CYP3A4ALDH1A1L3MBTL1CYP19A1PARP1
SCHEMBL31026612 0.78 SMN1; SMN2 (0.44) CYP3A4ALDH1A1TSHRTDP1
SCHEMBL11686437 0.76 FDPS (0.43) ALDH1A1FDPS
SCHEMBL29234310 0.73 NR3C2 (0.51) ALDH1A1PARP1
SCHEMBL1648730 0.71 CYP3A4 (0.42) CYP3A4ALDH1A1TSHRTDP1L3MBTL1
SCHEMBL28867968 0.70 PDE4A (0.37) CYP3A4ALDH1A1TSHRPARP1KMT2A
SCHEMBL4256418 0.68 AGTR1 (0.41) CYP3A4ALDH1A1TSHRTDP1L3MBTL1
SCHEMBL7908694 0.67 ALDH1A1 (0.53) CYP3A4ALDH1A1TSHRTDP1L3MBTL1
SCHEMBL19468241 0.65 CYP11B1 (0.34) ALDH1A1CYP11B1CYP11B2CYP19A1KMT2A
SCHEMBL31647881 0.65 PARP1 (0.36) PARP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025243042-A1 COMPOUNDS FOR THE INHIBITION OF CYCLOPHILIN D THE UNIVERSITY OF LIVERPOOL (GB) 2025-11-27 WO disclosed