Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.63 |
| ▸ | GGPS1 | O95749 | 1/20 | 0.59 |
| ▸ | FDPS | P14324 | 1/20 | 0.59 |
| ▸ | APAF1 | O14727 | 1/20 | 0.58 |
| ▸ | CYP11B1 | P15538 | 5/20 | 0.56 |
| ▸ | CYP11B2 | P19099 | 5/20 | 0.56 |
| ▸ | TNF | P01375 | 1/20 | 0.56 |
| ▸ | AGER | Q15109 | 4/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6791275 | 0.81 | GGPS1 (0.64) | TDP1GGPS1FDPSAPAF1CYP11B1 | |
| SCHEMBL1026002 | 0.81 | APAF1 (0.67) | TDP1GGPS1FDPSAPAF1CYP11B1 | |
| SCHEMBL19432570 | 0.80 | APAF1 (0.65) | TDP1GGPS1FDPSAPAF1CYP11B1 | |
| SCHEMBL6175278 | 0.79 | APAF1 (0.68) | TDP1GGPS1FDPSAPAF1CYP11B1 | |
| SCHEMBL14408911 | 0.79 | APAF1 (0.63) | TDP1GGPS1FDPSAPAF1CYP11B1 | |
| SCHEMBL30899626 | 0.79 | GGPS1 (0.43) | TDP1GGPS1FDPSAPAF1POLB | |
| SCHEMBL6176569 | 0.79 | APAF1 (0.68) | TDP1GGPS1FDPSAPAF1CYP11B1 | |
| SCHEMBL30899625 | 0.79 | PRPS1 (0.43) | TDP1GGPS1FDPSAPAF1AGER | |
| SCHEMBL6125455 | 0.79 | TDP1 (0.70) | TDP1GGPS1FDPSCYP11B1CYP11B2 | |
| SCHEMBL6794361 | 0.78 | TDP1 (0.76) | TDP1GGPS1FDPSCYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250387397-A1 | SUBSTITUTED AMINO TRIAZOLOPYRIMIDINE AND AMINO TRIAZOLOPYRAZINE ADENOSINE RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITIONS AND THEIR USE | MERCK SHARP & DOHME LLC (US) | 2025-12-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250387397-A1 | SUBSTITUTED AMINO TRIAZOLOPYRIMIDINE AND AMINO TRIAZOLOPYRAZINE ADENOSINE RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITIONS AND THEIR USE | ADORA2A, ADORA2B, ADORA1 | TDP1 1789/4885GGPS1 1579/4885FDPS 3024/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.