Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.32 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17074654 | 0.72 | ALDH1A1 (0.31) | ALDH1A1KMT2A | |
| SCHEMBL31747820 | 0.72 | CHRM2 (0.34) | ALDH1A1KMT2A | |
| SCHEMBL28065851 | 0.71 | CYP1A2 (0.35) | — | |
| SCHEMBL31747867 | 0.70 | KMT2A (0.40) | ALDH1A1KMT2A | |
| SCHEMBL31747874 | 0.69 | ADRA1A (0.36) | ALDH1A1KMT2AALOX5AP | |
| SCHEMBL1673128 | 0.68 | — | — | |
| SCHEMBL31747886 | 0.68 | AKT1 (0.42) | ALDH1A1KMT2A | |
| SCHEMBL31747993 | 0.67 | ALDH1A1 (0.50) | ALDH1A1KMT2A | |
| SCHEMBL31747917 | 0.67 | MAPT (0.44) | ALDH1A1KMT2A | |
| SCHEMBL11055567 | 0.65 | ALDH1A1 (0.45) | ALDH1A1KMT2ACHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250388543-A1 | HETEROARYL COMPOUNDS FOR THE TREATMENT OF PAIN | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2025-12-25 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250388543-A1 | HETEROARYL COMPOUNDS FOR THE TREATMENT OF PAIN | SCN8A, SCN1B, SCN3A | ALDH1A1 2279/4885KMT2A 3307/4885CHRNB4 119/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.