SCHEMBL317656

SCHEMBL317656

O=C(O)c1cccc(N2C(=O)CCC2=O)c1F

nearest known ligand 0.45

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
TTR P02766 1/20 0.44
CA12 O43570 1/20 0.42
CA1 P00915 1/20 0.42
CA9 Q16790 1/20 0.42
ALDH1A1 P00352 2/20 0.42
ALOX15 P16050 1/20 0.42
MAPK1 P28482 1/20 0.41
ALB P02768 1/20 0.41
GAA P10253 2/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
NOTUM Q6P988 2/20 0.38
MYC P01106 2/20 0.38
KMT2A Q03164 2/20 0.38
NR4A1 P22736 1/20 0.38
MAPT P10636 1/20 0.38
KDM4E B2RXH2 2/20 0.37
PKM P14618 1/20 0.37
MEN1 O00255 1/20 0.37
ATM Q13315 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9262225 0.82 GAA (0.55) CA12CA1CA9ALDH1A1ALOX15
SCHEMBL11564833 0.81 ALDH1A1 (0.43) CA12CA1CA9ALDH1A1ALOX15
SCHEMBL15636976 0.81 ALDH1A1 (0.43) CA12CA1CA9ALDH1A1ALOX15
SCHEMBL5853684 0.78 ALDH1A1 (0.51) TTRALDH1A1GAAL3MBTL1KMT2A
SCHEMBL317655 0.77 ALB (0.49) CA12CA1CA9ALDH1A1ALOX15
SCHEMBL3729139 0.76 TSHR (0.46) CA12CA1CA9ALDH1A1ALOX15
SCHEMBL6512006 0.76 AKR1C3 (0.51) CA12CA1CA9ALDH1A1ALOX15
SCHEMBL28755352 0.76 TLR9 (0.45) CA12CA1CA9ALDH1A1ALOX15
SCHEMBL11563899 0.75 GAA (0.47) CA12CA1CA9ALDH1A1ALOX15
SCHEMBL30740619 0.75 TTR (0.58) TTRALDH1A1ALOX15MAPK1ALB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114173877-B Novel therapeutic vectors and prodrugs for the treatment of cancer 施科友智能化学疗法公司 2024-12-10 CN disclosed
EP-1827239-B1 POSITRON EMISSION TOMOGRAPHY IMAGING METHOD PURDUE RESEARCH FOUNDATION (US) 2019-04-17 EP disclosed
EP-2452695-A2 Positron emission tomography imaging method Purdue Research Foundation (US) 2012-05-16 EP disclosed
US-8093405-B2 Formation of 18F and 19F fluoroarenes bearing reactive functionalities UNIVERSITY OF NEWCASTLE UPON TYNE (GB) 2012-01-10 US disclosed
EP-2310362-A1 FORMATION OF 18F AND 19F FLUOROARENES BEARING REACTIVE FUNCTIONALITIES University Of Newcastle-Upon Tyne (GB) 2011-04-20 EP disclosed
WO-2009138763-A1 FORMATION OF 18F AND 19F FLUOROARENES BEARING REACTIVE FUNCTIONALITIES UNIVERSITY OF NEWCASTLE UPON TYNE (GB) 2009-11-19 WO disclosed
US-20090286992-A1 FORMATION OF 18F AND 19F FLUOROARENES BEARING REACTIVE FUNCTIONALITIES UNIVERSITY OF NEWCASTLE UPON TYNE (GB) 2009-11-19 US disclosed
EP-1827239-A4 POSITRON EMISSION TOMOGRAPHY IMAGING METHOD PURDUE RESEARCH FOUNDATION (US) 2009-07-22 EP disclosed
US-20070276231-A1 Positron Emission Tomography Imaging Method PURDUE RESEARCH FOUNDATION 2007-11-29 US disclosed
EP-1827239-A2 POSITRON EMISSION TOMOGRAPHY IMAGING METHOD PURDUE RESEARCH FOUNDATION (US) 2007-09-05 EP disclosed
WO-2006071754-A2 POSITRON EMISSION TOMOGRAPHY IMAGING METHOD PURDUE RESEARCH FOUNDATION (US) 2006-07-06 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090286992-A1 FORMATION OF 18F AND 19F FLUOROARENES BEARING REACTIVE FUNCTIONALITIES RARB, RARG, RARA TTR 1542/4885CA12 316/4885CA1 638/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.