SCHEMBL317706

SCHEMBL317706

O=c1cc(CCl)[nH]c(=O)[nH]1

nearest known ligand 0.50

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
GPR84 Q9NQS5 1/20 0.50
RAB9A P51151 1/20 0.47
SMN1; SMN2 Q16637 3/20 0.46
CA1 P00915 1/20 0.44
MAPT P10636 1/20 0.44
TYMP P19971 2/20 0.43
TSHR P16473 2/20 0.43
HSD17B10 Q99714 2/20 0.43
L3MBTL1 Q9Y468 1/20 0.43
HTT P42858 2/20 0.41
THRB P10828 1/20 0.41
ALDH1A1 P00352 2/20 0.41
UNG P13051 1/20 0.41
CASP1 P29466 1/20 0.41
CASP7 P55210 1/20 0.41
LMNA P02545 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4561073 1.00 GPR84 (0.50) GPR84RAB9ASMN1; SMN2CA1MAPT
SCHEMBL1272345 0.82 GPR84 (0.56) GPR84RAB9ASMN1; SMN2CA1TYMP
SCHEMBL28903016 0.78 MAPT (0.40) GPR84RAB9ASMN1; SMN2MAPTTSHR
SCHEMBL9220998 0.76 GPR84 (0.50) GPR84RAB9ASMN1; SMN2CA1MAPT
SCHEMBL11844328 0.76 GPR84 (0.50) GPR84RAB9ASMN1; SMN2CA1MAPT
SCHEMBL18018476 0.76 GPR84 (0.50) GPR84RAB9ASMN1; SMN2CA1MAPT
SCHEMBL2959182 0.76 GPR84 (0.50) GPR84RAB9ASMN1; SMN2CA1MAPT
SCHEMBL5508748 0.76 GPR84 (0.50) GPR84RAB9ASMN1; SMN2CA1MAPT
SCHEMBL5071203 0.76 GPR84 (0.60) GPR84RAB9ASMN1; SMN2CA1MAPT
SCHEMBL22851529 0.73 GPR84 (0.47) GPR84RAB9ASMN1; SMN2CA1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 443 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4560315-A2 HYBRIDIZING ALL-LNA OLIGONUCLEOTIDES F. Hoffmann-La Roche AG (CH) 2025-05-28 EP claimed
EP-3980554-B1 HYBRIDIZING ALL-LNA OLIGONUCLEOTIDES HOFFMANN LA ROCHE (CH) 2025-03-26 EP claimed
CN-115947692-B Method for preparing 2-chloro-4- (methoxymethyl) pyrimidine 上海再启生物技术有限公司 2024-12-27 CN claimed
CN-115947692-A Method for preparing 2-chloro-4- (methoxymethyl) pyrimidine 上海再启生物技术有限公司 2023-04-11 CN claimed
CN-115785486-A Preparation method of polyion liquid hydrogel with high tensile strength, toughness, rapid recovery and fatigue resistance 黑龙江省科学院高技术研究院 2023-03-14 CN claimed
US-11465988-B2 Process for the preparation of Tipiracil hydrochloride and intermediates thereof NATCO PHARMA LIMITED (IN) 2022-10-11 US claimed
US-20220195497-A1 HYBRIDIZING all-LNA OLIGONUCLEOTIDES ROCHE DIAGNOSTICS OPERATIONS, INC. 2022-06-23 US claimed
EP-3759082-B1 PROCESS FOR THE SYNTHESIS OF 6-CHLOROMETHYLURACIL PROCOS SPA (IT) 2022-04-20 EP claimed
EP-3980554-A1 HYBRIDIZING ALL-LNA OLIGONUCLEOTIDES F. Hoffmann-La Roche AG (CH) 2022-04-13 EP claimed
US-20220056016-A1 IMPROVED PROCESS FOR THE PREPARATION OF TIPIRACIL HYDROCHLORIDE AND INTERMEDIATES THEREOF NATCO PHARMA LIMITED (IN) 2022-02-24 US claimed
CN-105367546-A A preparing process of alogliptin benzoate BEIJING DOCTORANTE TECH DEV CO LTD 2016-03-02 CN claimed
CN-103980249-B A kind of process for purification of SYR-322 XINXING MEDICAMENT DEVELOPMENT CO., LTD., ANHUI PROV. (CN) 2016-01-20 CN claimed
CN-105017161-A Compound, and preparation method and applications thereof NANJING BIODEALPHARM CO LTD 2015-11-04 CN claimed
CN-104592195-A A preparing process of alogliptin benzoate JIANGSU WANBANG BIOPHARMACEUTICALS CO LTD 2015-05-06 CN claimed
CN-104402832-A Preparation method of dihydropyrimidine derivative GUANGDONG HEC PHARMACEUTICAL 2015-03-11 CN claimed
CN-104311535-A Method for preparing DPP-IV inhibitor GUANGDONG HEC PHARMACEUTICAL 2015-01-28 CN claimed
CN-104193726-A Synthesis method of alogliptin benzoate JIANGSU DEYUAN PHARMACEUTICAL CO LTD 2014-12-10 CN claimed
CN-103980249-A Method for refining alogliptin benzoate ANHUI NEW STAR PHARMACEUTICAL DEV CO LTD 2014-08-13 CN claimed
EP-0177574-B1 AMINOCARNITINES CORNELL RESEARCH FOUNDATION, INC. (US) 1989-12-20 EP claimed
US-4781863-A FROM 6-CHLOROMETHYLURACIL CORNELL RESEARCH FOUNDATION, INC. (US) 1988-11-01 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220056016-A1 IMPROVED PROCESS FOR THE PREPARATION OF TIPIRACIL HYDROCHLORIDE AND INTERMEDIATES THEREOF DHPS, MTHFD1, DHFR GPR84 3918/4885RAB9A 1700/4885SMN1; SMN2 2445/4885
US-11465988-B2 Process for the preparation of Tipiracil hydrochloride and intermediates thereof DHPS, MTHFD1, DPYD GPR84 3847/4885RAB9A 1622/4885SMN1; SMN2 2761/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.