Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Acetylcholine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 known ✓ | P20309 | 8/20 | 0.95 |
| ▸ | GALR3 | O60755 | 2/20 | 1.00 |
| ▸ | GAA | P10253 | 1/20 | 1.00 |
| ▸ | RAB9A | P51151 | 1/20 | 1.00 |
| ▸ | CHRM1 | P11229 | 8/20 | 0.95 |
| ▸ | CHRM2 | P08172 | 7/20 | 0.95 |
| ▸ | CHRM4 | P08173 | 7/20 | 0.95 |
| ▸ | CHRM5 | P08912 | 6/20 | 0.95 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.95 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.95 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.95 |
| ▸ | HTR1A | P08908 | 2/20 | 0.95 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.95 |
| ▸ | PGR | P06401 | 1/20 | 0.95 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.95 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.95 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.95 |
| ▸ | CHRNA10 | Q9GZZ6 | 1/20 | 0.95 |
| ▸ | CHRNA9 | Q9UGM1 | 1/20 | 0.95 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetylcholine SCHEMBL2518957 | 0.97 | CHRM1 (1.00) | GALR3GAARAB9ACHRM1CHRM3 | |
| Acetylcholine SCHEMBL3216 | 0.97 | CHRM1 (1.00) | GALR3GAARAB9ACHRM1CHRM3 | |
| Acetylcholine SCHEMBL28024216 | 0.95 | GALR3 (0.91) | GALR3GAARAB9ACHRM1CHRM3 | |
| Acetylcholine SCHEMBL3904052 | 0.95 | CHRM1 (0.95) | GALR3GAARAB9ACHRM1CHRM3 | |
| Acetylcholine SCHEMBL6023859 | 0.95 | CHRM1 (0.95) | GALR3GAARAB9ACHRM1CHRM3 | |
| Acetylcholine SCHEMBL1899186 | 0.95 | CHRM1 (0.95) | GALR3GAARAB9ACHRM1CHRM3 | |
| Acetylcholine SCHEMBL8513991 | 0.95 | CHRM1 (0.95) | GALR3GAARAB9ACHRM1CHRM3 | |
| Acetylcholine SCHEMBL21925712 | 0.95 | CHRM1 (0.95) | GALR3GAARAB9ACHRM1CHRM3 | |
| Acetylcholine SCHEMBL18227923 | 0.95 | CHRM1 (0.95) | GALR3GAARAB9ACHRM1CHRM3 | |
| Acetylcholine SCHEMBL15687718 | 0.95 | CHRM1 (0.95) | GALR3GAARAB9ACHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 379 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240279551-A1 | LIQUID CRYSTAL EMULSIONS AND USES THEREOF | CORNELL UNIVERSITY | 2024-08-22 | — | — | US | claimed |
| CN-118420928-A | Ionic liquid modified polyvinyl alcohol gel and preparation method and application thereof | 中国科学院上海硅酸盐研究所 | 2024-08-02 | — | — | CN | claimed |
| CN-117939894-A | Perovskite solar cell and preparation method thereof | 武汉大学 | 2024-04-26 | — | — | CN | claimed |
| CN-116773803-A | Kit for detecting AChR blocking antibody, detection method and application | 陕西脉元生物科技有限公司 | 2023-09-19 | — | — | CN | claimed |
| US-20230086996-A1 | Binder Compositions and Composite | GEORGIA-PACIFIC CHEMICALS LLC (US) | 2023-03-23 | — | — | US | claimed |
| CN-115656505-A | Kit for detecting AChR blocking antibody, detection method and application | 陕西脉元生物科技有限公司 | 2023-01-31 | — | — | CN | claimed |
| WO-2023283010-A2 | LIQUID CRYSTAL EMULSIONS AND USES THEREOF | CORNELL UNIVERSITY (US) | 2023-01-12 | — | — | WO | claimed |
| EP-4093821-A1 | BINDER COMPOSITIONS AND COMPOSITE | Georgia-Pacific Chemicals LLC (US) | 2022-11-30 | — | — | EP | claimed |
| CN-109502604-B | Method for preparing Y-type molecular sieve with high silicon-aluminum ratio | 中国科学院大连化学物理研究所 | 2021-12-21 | — | — | CN | claimed |
| WO-2021148964-A1 | BINDER COMPOSITIONS AND COMPOSITE | GEORGIA-PACIFIC CHEMICALS LLC (US) | 2021-07-29 | — | — | WO | claimed |
| CN-102125691-A | Nano-medicament carrying system of acetylcholine medicament | INST PHARM & TOXICOLOGY AMMS | 2011-07-20 | — | — | CN | claimed |
| US-20110040248-A1 | METHODS AND IMPLANTABLE DEVICES FOR TREATING SUPRAVENTRICULAR ARRHYTHMIAS | CLOSED LOOP THERAPIES BV (NL) | 2011-02-17 | — | — | US | claimed |
| US-7781402-B2 | Methods and implantable devices for treating supraventricular arrhythmias | CLOSED LOOP THERAPIES LTD. (IL) | 2010-08-24 | — | — | US | claimed |
| EP-1809374-A4 | METHODS AND IMPLANTABLE DEVICES FOR TREATING SUPRAVENTRICULAR ARRHYTHMIAS | CLOSED LOOP THERAPIES LTD (IL) | 2008-09-10 | — | — | EP | claimed |
| EP-1809374-A1 | METHODS AND IMPLANTABLE DEVICES FOR TREATING SUPRAVENTRICULAR ARRHYTHMIAS | Closed Loop Therapies Ltd. (IL) | 2007-07-25 | — | — | EP | claimed |
| WO-2006040765-A1 | METHODS AND IMPLANTABLE DEVICES FOR TREATING SUPRAVENTRICULAR ARRHYTHMIAS | CLOSED LOOP THERAPIES LTD. (IL) | 2006-04-20 | — | — | WO | claimed |
| US-20060079941-A1 | Methods and implantable devices for treating supraventricular arrhythmias | CLOSED LOOP THERAPIES LTD. (IL) | 2006-04-13 | — | — | US | claimed |
| US-20040154231-A1 | Chemical mechanical polishing slurry | LEE JAE-DONG (KR) | 2004-08-12 | — | — | US | claimed |
| US-20020123224-A1 | Chemical mechanical polishing slurry | SAMSUNG ELECTRONICS CO., LTD. (KR) | 2002-09-05 | — | — | US | claimed |
| US-6395077-B1 | INKS WITH BENZOYLBENZOIC ACID AND COLORS | XEROX CORPORATION | 2002-05-28 | — | — | US | claimed |