Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Acetylcholine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 known ✓ | P20309 | 8/20 | 0.95 |
| ▸ | CHRM1 | P11229 | 8/20 | 0.95 |
| ▸ | CHRM2 | P08172 | 7/20 | 0.95 |
| ▸ | CHRM4 | P08173 | 7/20 | 0.95 |
| ▸ | CHRM5 | P08912 | 6/20 | 0.95 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.95 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.95 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.95 |
| ▸ | HTR1A | P08908 | 2/20 | 0.95 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.95 |
| ▸ | PGR | P06401 | 1/20 | 0.95 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.95 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.95 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.95 |
| ▸ | CHRNA10 | Q9GZZ6 | 1/20 | 0.95 |
| ▸ | CHRNA9 | Q9UGM1 | 1/20 | 0.95 |
| ▸ | GALR3 | O60755 | 2/20 | 0.91 |
| ▸ | GAA | P10253 | 1/20 | 0.91 |
| ▸ | RAB9A | P51151 | 1/20 | 0.91 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetylcholine SCHEMBL3216 | 0.97 | CHRM1 (1.00) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| Acetylcholine SCHEMBL2518957 | 0.97 | CHRM1 (1.00) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| Acetylcholine SCHEMBL18227923 | 0.95 | CHRM1 (0.95) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| Acetylcholine SCHEMBL21925712 | 0.95 | CHRM1 (0.95) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| Acetylcholine SCHEMBL1157050 | 0.95 | CHRM1 (0.95) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| Acetylcholine SCHEMBL1899186 | 0.95 | CHRM1 (0.95) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| Acetylcholine SCHEMBL6023859 | 0.95 | CHRM1 (0.95) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| Acetylcholine SCHEMBL8513991 | 0.95 | CHRM1 (0.95) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| Acetylcholine SCHEMBL3904052 | 0.95 | CHRM1 (0.95) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| Acetylcholine SCHEMBL40885 | 0.95 | CHRM5 (1.00) | CHRM1CHRM3CHRM2CHRM4CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11930694-B2 | Polymer semiconductors containing acrylyl or acrylyl-like side chain and their devices | UNIVERSITY OF WATERLOO (CA) | 2024-03-12 | — | — | US | disclosed |
| US-20210384435-A1 | POLYMER SEMICONDUCTORS CONTAINING ACRYLYL OR ACRYLYL-LIKE SIDE CHAIN AND THEIR DEVICES | UNIVERSITY OF WATERLOO (CA) | 2021-12-09 | — | — | US | disclosed |
| US-20150295179-A1 | MONOMERIC, OLIGOMERIC AND POLYMERIC SEMICONDUCTORS CONTAINING FUSED RINGS AND THEIR DEVICES | LI YUNING (US) | 2015-10-15 | — | — | US | disclosed |
| EP-2917261-A1 | MONOMERIC, OLIGOMERIC AND POLYMERIC SEMICONDUCTORS CONTAINING FUSED RINGS AND THEIR DEVICES | Li, Yuning (CA) | 2015-09-16 | — | — | EP | disclosed |
| WO-2014071524-A1 | MONOMERIC, OLIGOMERIC AND POLYMERIC SEMICONDUCTORS CONTAINING FUSED RINGS AND THEIR DEVICES | LI YUNING (CA) | 2014-05-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150295179-A1 | MONOMERIC, OLIGOMERIC AND POLYMERIC SEMICONDUCTORS CONTAINING FUSED RINGS AND THEIR DEVICES | PICALM, NOD2, CDH1 | CHRM3 579/4885CHRM1 237/4885CHRM2 459/4885 |
| US-11930694-B2 | Polymer semiconductors containing acrylyl or acrylyl-like side chain and their devices | OR10J3, PORCN, OSTC | CHRM3 946/4885CHRM1 2320/4885CHRM2 2164/4885 |
| US-20210384435-A1 | POLYMER SEMICONDUCTORS CONTAINING ACRYLYL OR ACRYLYL-LIKE SIDE CHAIN AND THEIR DEVICES | OR10J3, PORCN, OSTC | CHRM3 946/4885CHRM1 2320/4885CHRM2 2164/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.