Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 7/20 | 0.41 |
| ▸ | CASP1 | P29466 | 2/20 | 0.41 |
| ▸ | CASP7 | P55210 | 2/20 | 0.41 |
| ▸ | CASP9 | P55211 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 11/20 | 0.41 |
| ▸ | BACE2 | Q9Y5Z0 | 4/20 | 0.41 |
| ▸ | CASP8 | Q14790 | 5/20 | 0.40 |
| ▸ | CASP6 | P55212 | 3/20 | 0.40 |
| ▸ | CTSD | P07339 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | CPA1 | P15085 | 1/20 | 0.38 |
| ▸ | CPA2 | P48052 | 1/20 | 0.38 |
| ▸ | CPA4 | Q9UI42 | 1/20 | 0.38 |
| ▸ | CASP2 | P42575 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL78393 | 0.89 | CASP3 (0.42) | CASP3CASP1CASP7CASP9BACE1 | |
| SCHEMBL6569052 | 0.81 | BACE1 (0.46) | CASP3CASP1CASP7CASP9BACE1 | |
| SCHEMBL2168561 | 0.77 | CASP3 (0.41) | CASP3CASP1CASP7CASP9BACE1 | |
| SCHEMBL77937 | 0.75 | OPRD1 (0.51) | CASP3CASP1CASP7BACE1BACE2 | |
| SCHEMBL7163106 | 0.75 | BACE1 (0.50) | CASP3CASP1CASP7CASP9BACE1 | |
| SCHEMBL29396633 | 0.74 | KDM4E (0.41) | CASP3CASP1CASP7CASP9BACE1 | |
| SCHEMBL7165565 | 0.73 | CASP3 (0.55) | CASP3CASP1CASP7CASP9BACE1 | |
| SCHEMBL1552674 | 0.73 | KDM4E (0.53) | CASP3POLB | |
| SCHEMBL29445883 | 0.73 | KDM4E (0.53) | CASP3POLB | |
| SCHEMBL7166887 | 0.73 | CASP3 (0.54) | CASP3CASP1CASP7CASP9BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100190195-A1 | Use of Hepatitis B X-Interacting Protein (HBXIP) in Modulation of Apoptosis | THE BURNHAM INSTITUTE | 2010-07-29 | — | — | US | disclosed |
| US-7655634-B2 | Use of hepatitis B X-interacting protein (HBXIP) in modulation of apoptosis | THE BURNHAM INSTITUTE (US) | 2010-02-02 | — | — | US | disclosed |
| US-7393666-B2 | Use of hepatitis B X-interacting protein (HBXIP) in modulation of apoptosis | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2008-07-01 | — | — | US | disclosed |
| US-20070270369-A1 | USE OF HEPATITIS B X-INTERACTING PROTEIN (HBXIP) IN MODULATION OF APOPTOSIS | THE BURNHAM INSTITUTE (US) | 2007-11-22 | — | — | US | disclosed |
| US-20060205008-A1 | Use of hepatitis B X-interacting protein (HBXIP) in modulation of apoptosis | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2006-09-14 | — | — | US | disclosed |
| US-20040138119-A1 | RNA interference or gene expression inhibitors as blocking agents for complexing of endogenous cellular proteins with survivin, intensifying programmed cell death; antitumor or anticarcinogenic agents | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2004-07-15 | — | — | US | disclosed |