Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 18/20 | 0.46 |
| ▸ | BACE2 | Q9Y5Z0 | 5/20 | 0.46 |
| ▸ | CTSD | P07339 | 2/20 | 0.46 |
| ▸ | CASP3 | P42574 | 2/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | CASP9 | P55211 | 1/20 | 0.41 |
| ▸ | CASP6 | P55212 | 1/20 | 0.40 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL78393 | 0.92 | CASP3 (0.42) | BACE1BACE2CTSDCASP3CASP1 | |
| SCHEMBL6570634 | 0.83 | OPRD1 (0.57) | BACE1BACE2CASP1 | |
| SCHEMBL7408879 | 0.81 | POLB (0.47) | — | |
| SCHEMBL3178459 | 0.81 | CASP3 (0.41) | BACE1BACE2CTSDCASP3CASP1 | |
| SCHEMBL4321426 | 0.78 | BACE1 (0.44) | BACE1BACE2CTSDCASP3CASP1 | |
| SCHEMBL77937 | 0.78 | OPRD1 (0.51) | BACE1BACE2CASP3CASP1CASP7 | |
| SCHEMBL29470083 | 0.76 | KDM4E (0.52) | BACE1BACE2CTSD | |
| SCHEMBL31089740 | 0.74 | ENPEP (0.55) | BACE1BACE2CTSD | |
| SCHEMBL5194261 | 0.74 | ENPEP (0.55) | BACE1BACE2CTSD | |
| SCHEMBL19794 | 0.73 | BACE1 (0.52) | BACE1BACE2CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1406866-A1 | INHIBITORS OF THE ICE/CED-3 FAMILY OF CYSTEINE PROTEASES | Idun Pharmaceuticals, Inc. (US) | 2004-04-14 | — | — | EP | disclosed |
| WO-2003008374-A1 | INHIBITORS OF THE ICE/CED-3 FAMILY OF CYSTEINE PROTEASES | IDUN PHARMACEUTICALS, INC. (US) | 2003-01-30 | — | — | WO | disclosed |
| EP-1091980-A1 | COMPOSITIONS AND METHODS FOR IDENTIFYING APOPTOSIS SIGNALING PATHWAY INHIBITORS AND ACTIVATORS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2001-04-18 | — | — | EP | disclosed |
| WO-1999055134-A2 | COMPOSITIONS AND METHODS FOR IDENTIFYING APOPTOSIS SIGNALING PATHWAY INHIBITORS AND ACTIVATORS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 1999-11-04 | — | — | WO | disclosed |