Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCQ | Q04759 | 12/20 | 0.58 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.55 |
| ▸ | SIRT5 | Q9NXA8 | 2/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.45 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3180778 | 0.90 | PRKCQ (0.58) | PRKCQSTK17ASIRT5CYP1A2CYP3A4 | |
| SCHEMBL3183582 | 0.89 | SIRT5 (0.65) | PRKCQSIRT5CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL3189351 | 0.89 | PRKCQ (0.60) | PRKCQSTK17ASIRT5 | |
| SCHEMBL3179956 | 0.88 | PRKCQ (0.49) | PRKCQSTK17ASIRT5CYP1A2CYP3A4 | |
| SCHEMBL1916510 | 0.88 | STK17A (0.72) | PRKCQSTK17ACYP1A2CYP3A4CYP2C19 | |
| SCHEMBL3190820 | 0.87 | SIRT5 (0.49) | PRKCQSTK17ASIRT5CYP1A2CYP3A4 | |
| SCHEMBL3182009 | 0.86 | PRKCQ (0.49) | PRKCQSTK17ASIRT5CYP1A2CYP3A4 | |
| SCHEMBL3186194 | 0.83 | VNN1 (0.46) | PRKCQSTK17ASIRT5PKM | |
| SCHEMBL4387931 | 0.82 | PRKCQ (0.67) | PRKCQSTK17ASIRT5PKMCYP3A4 | |
| SCHEMBL5406390 | 0.82 | PRKCQ (0.64) | PRKCQSTK17APKMMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100113463-A1 | PTERIDINONE DERIVATIVES FOR USE AS STEAROYL CoA DESATURASE INHIBITORS | GILEAD PALO ALTO, INC. (US) | 2010-05-06 | — | — | US | disclosed |
| US-7662819-B2 | Pteridinone derivatives for use as stearoyl CoA desaturase inhibitors | GILEAD PALO ALTO, INC. (US) | 2010-02-16 | — | — | US | disclosed |
| US-20080249100-A1 | PTERIDINONE DERIVATIVES FOR USE AS STEAROYL CoA DESATURASE INHIBITORS | LIGAND PHARMACEUTICALS INCORPORATED | 2008-10-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100113463-A1 | PTERIDINONE DERIVATIVES FOR USE AS STEAROYL CoA DESATURASE INHIBITORS | SCD, SCD5, COASY | PRKCQ 2198/4885STK17A 237/4885SIRT5 70/4885 |
| US-20080249100-A1 | PTERIDINONE DERIVATIVES FOR USE AS STEAROYL CoA DESATURASE INHIBITORS | SCD, SCD5, COASY | PRKCQ 2198/4885STK17A 237/4885SIRT5 70/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.