Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCKBR | P32239 | 2/20 | 0.52 |
| ▸ | BRD4 | O60885 | 2/20 | 0.48 |
| ▸ | PREP | P48147 | 2/20 | 0.46 |
| ▸ | ACE | P12821 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.43 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.43 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.43 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.43 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.43 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10375649 | 0.85 | CCKBR (0.45) | CCKBRBRD4PREPACEKMT2A | |
| SCHEMBL3203712 | 0.84 | ALDH1A1 (0.46) | BRD4KMT2AMEN1HPGDTSHR | |
| SCHEMBL4920256 | 0.83 | CCKBR (0.53) | CCKBRBRD4PREPACEKMT2A | |
| SCHEMBL7020611 | 0.83 | CCKBR (0.53) | CCKBRBRD4PREPACEKMT2A | |
| SCHEMBL13484174 | 0.81 | HPGD (0.47) | BRD4PREPKMT2AMEN1HPGD | |
| SCHEMBL20875929 | 0.81 | CCKBR (0.51) | CCKBRBRD4PREPACEKMT2A | |
| SCHEMBL9766998 | 0.80 | HPGD (0.46) | BRD4PREPKMT2APOLBCYP2D6 | |
| SCHEMBL15488963 | 0.79 | HPGD (0.55) | KMT2AHPGDTSHRSMN1; SMN2 | |
| SCHEMBL30216631 | 0.79 | CA1 (0.56) | KMT2APOLBMEN1SMN1; SMN2 | |
| SCHEMBL3201676 | 0.78 | DPP4 (0.50) | BRD4PREPACEKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE41149-E1 | Stereoisomerically pure 7-[(7S)-7-amino-5-azaspiro[2.4]heptan-5-yl]-6-fluoro-1-[(1R,2S)-2-fluoro-1-cyclopropyl]-8-methoxy-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid or a pharmaceutically acceptable salt thereof; antibacterial agents | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2010-02-23 | — | — | US | disclosed |
| US-RE41149-E1 | Stereoisomerically pure 7-[(7S)-7-amino-5-azaspiro[2.4]heptan-5-yl]-6-fluoro-1-[(1R,2S)-2-fluoro-1-cyclopropyl]-8-methoxy-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid or a pharmaceutically acceptable salt thereof; antibacterial agents | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2010-02-23 | — | — | US | disclosed |
| US-6031102-A | Optically active pyridonecarboxylic acid derivatives | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2000-02-29 | — | — | US | disclosed |
| US-5767127-A | BACTERICIDES | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1998-06-16 | — | — | US | disclosed |
| US-5587386-A | BACTERICIDES, MICROBIOCIDES | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1996-12-24 | — | — | US | disclosed |