Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCKBR | P32239 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | PREP | P48147 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.44 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.44 |
| ▸ | ACE | P12821 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.43 |
| ▸ | FUCA1 | P04066 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7020611 | 1.00 | CCKBR (0.53) | CCKBRKMT2AMEN1PREPPOLB | |
| SCHEMBL3179986 | 0.83 | CCKBR (0.52) | CCKBRKMT2AMEN1PREPPOLB | |
| SCHEMBL4708947 | 0.82 | MEN1 (0.48) | KMT2AMEN1HPGDTSHR | |
| SCHEMBL4711716 | 0.82 | MEN1 (0.48) | KMT2AMEN1HPGDTSHR | |
| SCHEMBL10483634 | 0.82 | KMT2A (0.56) | KMT2AMEN1PREPPOLBCYP2D6 | |
| SCHEMBL20875929 | 0.82 | CCKBR (0.51) | CCKBRKMT2AMEN1PREPPOLB | |
| SCHEMBL10341454 | 0.79 | KMT2A (0.49) | CCKBRKMT2AMEN1PREPPOLB | |
| SCHEMBL20722523 | 0.77 | KMT2A (0.50) | KMT2AMEN1POLBCYP2D6CYP2C9 | |
| SCHEMBL20722526 | 0.77 | KMT2A (0.50) | KMT2AMEN1POLBCYP2D6CYP2C9 | |
| SCHEMBL20722524 | 0.77 | KMT2A (0.50) | KMT2AMEN1POLBCYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8183019-B2 | (3R,4R)-3-hydroxy-4-hydroxymethylpyrrolidine or (3S,4S)-3-hydroxy-4-hydroxymethylpyrrolidine; enzyme-catalysed enantioselective hydrolysis of a racemic 3,4-trans-disubstituted pyrrolidinone; for purine nucleoside phosphorylase (PNP) inhibitors | INDUSTRIAL RESEARCH LIMITED (NZ) | 2012-05-22 | — | — | US | disclosed |
| US-8183019-B2 | (3R,4R)-3-hydroxy-4-hydroxymethylpyrrolidine or (3S,4S)-3-hydroxy-4-hydroxymethylpyrrolidine; enzyme-catalysed enantioselective hydrolysis of a racemic 3,4-trans-disubstituted pyrrolidinone; for purine nucleoside phosphorylase (PNP) inhibitors | INDUSTRIAL RESEARCH LIMITED (NZ) | 2012-05-22 | — | — | US | disclosed |
| US-20080280334-A1 | Method for Preparing 3-Hydroxy-4-Hydroxymethyl-Pyrrolidine Compounds | ALBERT EINSTEIN COLLEGE OF MEDICINE | 2008-11-13 | — | — | US | disclosed |
| US-20080280334-A1 | Method for Preparing 3-Hydroxy-4-Hydroxymethyl-Pyrrolidine Compounds | ALBERT EINSTEIN COLLEGE OF MEDICINE | 2008-11-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080280334-A1 | Method for Preparing 3-Hydroxy-4-Hydroxymethyl-Pyrrolidine Compounds | HPD, DHPS, CYP3A5 | CCKBR 3327/4885KMT2A 1957/4885MEN1 3068/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.