SCHEMBL3182292

SCHEMBL3182292

O=C1C=C(c2c(Nc3ccccc3)ccc3ccccc23)C(=O)N1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.44
HPGD P15428 3/20 0.44
CYP3A4 P08684 2/20 0.44
CDC25B P30305 2/20 0.44
TP53 P04637 1/20 0.44
ALOX15 P16050 1/20 0.44
TSHR P16473 1/20 0.44
ATM Q13315 1/20 0.44
HSD17B10 Q99714 1/20 0.44
PRKCB P05771 6/20 0.41
PRKCA P17252 6/20 0.41
PRKD3 O94806 5/20 0.41
PRKCG P05129 5/20 0.41
PRKCH P24723 5/20 0.41
PRKCI P41743 5/20 0.41
PRKCE Q02156 5/20 0.41
PRKCQ Q04759 5/20 0.41
PRKCZ Q05513 5/20 0.41
PRKCD Q05655 5/20 0.41
PRKD1 Q15139 5/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29588900 0.79 ALDH1A1 (0.47) ALDH1A1HPGDCYP3A4CDC25BTP53
SCHEMBL3762747 0.79 ALDH1A1 (0.47) ALDH1A1HPGDCYP3A4CDC25BTP53
SCHEMBL1617789 0.77 ALDH1A1 (0.64) ALDH1A1HPGDCYP3A4CDC25BTP53
SCHEMBL30392844 0.77 ALDH1A1 (0.64) ALDH1A1HPGDCYP3A4CDC25BTP53
SCHEMBL5405972 0.77 DNMT1 (0.45) ALDH1A1HPGDTP53PRKCBPRKCA
SCHEMBL9228115 0.76 CYP1A2 (0.42) ALDH1A1HPGDTSHRPRKCBPRKCA
SCHEMBL31669073 0.76 CYP1A2 (0.42) ALDH1A1HPGDTSHRPRKCBPRKCA
SCHEMBL11882241 0.76 PRKCB (0.40) ALDH1A1HPGDCYP3A4TSHRHSD17B10
SCHEMBL10697862 0.74 MAPT (0.51) ALDH1A1HPGDCYP3A4CDC25BTP53
SCHEMBL31243247 0.73 ALDH1A1 (0.58) ALDH1A1HPGDCYP3A4CDC25BTP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101638523-B Ph-sensitive probe comprising polymer and fluorescent dye CANON KK 2014-05-28 CN disclosed
EP-2151249-A1 PH-sensitive probe comprising polymer and fluorescent dye Canon Kabushiki Kaisha (JP) 2010-02-10 EP disclosed
US-20100022759-A1 POLYMER AND FLUORESCENCE PROBE HAVING THE POLYMER CANON KABUSHIKI KAISHA (JP) 2010-01-28 US disclosed
US-20050208671-A1 Method of analyzing the ratio of activation of terminals of polyoxyalkylene derivatives NOF CORPORATION (JP) 2005-09-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100022759-A1 POLYMER AND FLUORESCENCE PROBE HAVING THE POLYMER COIL, PUF60, PHF6 ALDH1A1 4336/4885HPGD 1188/4885CYP3A4 3844/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.