Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | CCR2 | P41597 | 11/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 4/20 | 0.32 |
| ▸ | PSEN2 | P49810 | 4/20 | 0.32 |
| ▸ | APH1B | Q8WW43 | 4/20 | 0.32 |
| ▸ | NCSTN | Q92542 | 4/20 | 0.32 |
| ▸ | APH1A | Q96BI3 | 4/20 | 0.32 |
| ▸ | PSENEN | Q9NZ42 | 4/20 | 0.32 |
| ▸ | MMP1 | P03956 | 3/20 | 0.32 |
| ▸ | MMP3 | P08254 | 2/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | MMP7 | P09237 | 1/20 | 0.31 |
| ▸ | MMP8 | P22894 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5872369 | 0.78 | CCR2 (0.43) | HTTCCR2PSEN1PSEN2APH1B | |
| Hydrochloric Acid SCHEMBL4197517 | 0.78 | CCR2 (0.37) | HTTCCR2L3MBTL1MMP1MMP3 | |
| SCHEMBL25134503 | 0.77 | L3MBTL1 (0.34) | HTTCCR2L3MBTL1 | |
| SCHEMBL7626955 | 0.76 | HTT (0.41) | HTTCCR2PSEN1PSEN2APH1B | |
| SCHEMBL11269081 | 0.75 | GRIN2D (0.39) | CCR2 | |
| SCHEMBL11280209 | 0.74 | CCR2 (0.40) | CCR2 | |
| Hydrochloric Acid SCHEMBL11261225 | 0.74 | GRIN2D (0.38) | CCR2 | |
| Hydrochloric Acid SCHEMBL319092 | 0.73 | L3MBTL1 (0.32) | HTTCCR2L3MBTL1 | |
| SCHEMBL6730325 | 0.73 | CTSD (0.38) | CCR2L3MBTL1MMP1MMP3MMP2 | |
| SCHEMBL24964008 | 0.73 | CTSD (0.38) | CCR2L3MBTL1MMP1MMP3MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2585447-A2 | COMPOUNDS AND METHODS FOR THE TREATMENT OR PREVENTION OF FLAVIVIRUS INFECTIONS | Vertex Pharmaceuticals Incorporated (US) | 2013-05-01 | — | — | EP | disclosed |
| WO-2012006055-A2 | COMPOUNDS AND METHODS FOR THE TREATMENT OR PREVENTION OF FLAVIVIRUS INFECTIONS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-01-12 | — | — | WO | disclosed |