Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.64 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.59 |
| ▸ | NR4A2 | P43354 | 4/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.49 |
| ▸ | MITF | O75030 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | APEX1 | P27695 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | RAD52 | P43351 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3063558 | 0.86 | NR4A2 (0.71) | MAPTL3MBTL1CRHR1NR4A2KDM4E | |
| SCHEMBL30827899 | 0.85 | LMNA (0.51) | MAPTL3MBTL1CRHR1NR4A2TP53 | |
| SCHEMBL7699184 | 0.85 | LMNA (0.51) | MAPTL3MBTL1CRHR1NR4A2TP53 | |
| Ammonia Solution, Strong SCHEMBL28093124 | 0.83 | LMNA (0.50) | MAPTL3MBTL1CRHR1NR4A2TP53 | |
| SCHEMBL8966258 | 0.82 | KDM4E (0.69) | MAPTL3MBTL1CRHR1NR4A2TP53 | |
| SCHEMBL20304317 | 0.81 | L3MBTL1 (0.44) | MAPTL3MBTL1CRHR1NR4A2TP53 | |
| SCHEMBL18197787 | 0.81 | NR4A2 (0.47) | MAPTL3MBTL1CRHR1NR4A2TP53 | |
| SCHEMBL661993 | 0.81 | MAPT (0.60) | MAPTL3MBTL1CRHR1NR4A2MEN1 | |
| SCHEMBL317207 | 0.81 | MAPT (0.60) | MAPTL3MBTL1CRHR1NR4A2KDM4E | |
| SCHEMBL3051550 | 0.81 | MAPT (0.60) | MAPTL3MBTL1CRHR1NR4A2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10316036-B2 | Substituted pyrazino[2,2-a]isoquinoline derivatives | HOFFMANN-LA ROCHE INC. (US) | 2019-06-11 | — | — | US | disclosed |
| EP-3186250-B1 | SUBSTITUTED PYRAZINO[2,1-A]ISOQUINOLINE DERIVATIVES FOR THE TREATMENT OF CNS DISORDERS | HOFFMANN LA ROCHE (CH) | 2018-04-18 | — | — | EP | disclosed |
| US-20180037582-A1 | SUBSTITUTED PYRAZINO[2,2-a]ISOQUINOLINE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2018-02-08 | — | — | US | disclosed |
| US-9828374-B2 | Substituted pyrazino[2,2-a]isoquinoline derivatives | HOFFMANN-LA ROCHE INC. (US) | 2017-11-28 | — | — | US | disclosed |
| EP-3186250-A1 | SUBSTITUTED PYRAZINO[2,1-A]ISOQUINOLINE DERIVATIVES FOR THE TREATMENT OF CNS DISORDERS | F. Hoffmann-La Roche AG (CH) | 2017-07-05 | — | — | EP | disclosed |
| US-20170145010-A1 | SUBSTITUTED PYRAZINO[2,2-a]ISOQUINOLINE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2017-05-25 | — | — | US | disclosed |
| CN-106470994-A | For treating substituted pyrazine simultaneously [2,1 A] isoquinilone derivatives of CNS disease | 豪夫迈·罗氏有限公司 | 2017-03-01 | — | — | CN | disclosed |
| WO-2016030306-A1 | SUBSTITUTED PYRAZINO[2,1-A]ISOQUINOLINE DERIVATIVES FOR THE TREATMENT OF CNS DISORDERS | F. HOFFMANN-LA ROCHE AG (CH) | 2016-03-03 | — | — | WO | disclosed |
| WO-2016022644-A1 | HETEROCYCLIC CGRP RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2016-02-11 | — | — | WO | disclosed |
| WO-2016022645-A1 | HETEROCYCLIC CGRP RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2016-02-11 | — | — | WO | disclosed |
| WO-2003101981-A1 | NOVEL SUBSTITUTED INDOLES | ASTRAZENECA AB (SE) | 2003-12-11 | — | — | WO | disclosed |
| EP-0113432-B1 | CHLOROMETHYL QUINOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE | ALKALOIDA VEGYéSZETI GYáR (HU) | 1993-03-17 | — | — | EP | disclosed |
| CN-1017244-B | Process for preparing triazolyl quinoline derivatives | ALKALOIDA WEGYESZETI GYAR (HU) | 1992-07-01 | — | — | CN | disclosed |
| US-5104884-A | Rheumatic diseases, fungicides | ALKALOIDA VEGYESZETI GYAR (HU) | 1992-04-14 | — | — | US | disclosed |
| EP-0221947-B1 | TRIAZOLYL QUINOLINE DERIVATIVES | ALKALOIDA VEGYéSZETI GYáR (HU) | 1990-11-28 | — | — | EP | disclosed |
| CN-86103997-A | The preparation method of triazolyl quinoline derivative class | — | 1987-12-30 | — | — | CN | disclosed |
| EP-0221947-A1 | TRIAZOLYL QUINOLINE DERIVATIVES. | ALKALOIDA VEGYESZETI GYAR (HU) | 1987-05-20 | — | — | EP | disclosed |
| WO-1986006721-A1 | TRIAZOLYL QUINOLINE DERIVATIVES | ALKALOIDA VEGYÉSZETI GYÁR (HU) | 1986-11-20 | — | — | WO | disclosed |
| US-4599345-A | BACTERICIDES, FUNGICIDES ANTIINFLAMMATORY | ALKALOIDE VEGYESZETI GYAR (HU) | 1986-07-08 | — | — | US | disclosed |
| EP-0113432-A1 | Chloromethyl quinoline derivatives, process for their preparation and their use | ALKALOIDA VEGYéSZETI GYáR (HU) | 1984-07-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170145010-A1 | SUBSTITUTED PYRAZINO[2,2-a]ISOQUINOLINE DERIVATIVES | HCRTR2, CYP11B2, CYP1A2 | MAPT 2352/4885L3MBTL1 1800/4885CRHR1 148/4885 |
| US-20180037582-A1 | SUBSTITUTED PYRAZINO[2,2-a]ISOQUINOLINE DERIVATIVES | HCRTR2, HCRTR1, CYP11B2 | MAPT 1870/4885L3MBTL1 2644/4885CRHR1 52/4885 |
| US-10316036-B2 | Substituted pyrazino[2,2-a]isoquinoline derivatives | HCRTR2, HCRTR1, CYP11B2 | MAPT 1870/4885L3MBTL1 2644/4885CRHR1 52/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.