Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 2/20 | 0.61 |
| ▸ | BCL2L1 | Q07817 | 3/20 | 0.53 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.53 |
| ▸ | ADAMTS4 | O75173 | 5/20 | 0.52 |
| ▸ | MMP13 | P45452 | 3/20 | 0.52 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.51 |
| ▸ | MMP2 | P08253 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | NEK1 | Q96PY6 | 2/20 | 0.49 |
| ▸ | GPR34 | Q9UPC5 | 1/20 | 0.49 |
| ▸ | PTGES | O14684 | 3/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.48 |
| ▸ | MMP1 | P03956 | 1/20 | 0.48 |
| ▸ | MMP9 | P14780 | 1/20 | 0.48 |
| ▸ | MMP14 | P50281 | 1/20 | 0.48 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.48 |
| ▸ | PGR | P06401 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1287447 | 0.88 | MMP2 (0.62) | ADAMTS4ADAMTS5MMP2NEK1MMP9 | |
| SCHEMBL1287449 | 0.88 | MMP2 (0.62) | ADAMTS4ADAMTS5MMP2NEK1MMP9 | |
| SCHEMBL9513663 | 0.83 | MMP2 (0.55) | ARBCL2L1MCL1ADAMTS5MMP2 | |
| SCHEMBL14602239 | 0.82 | MMP2 (0.79) | ARBCL2L1MCL1ADAMTS4MMP13 | |
| SCHEMBL9512132 | 0.81 | MMP2 (0.60) | ADAMTS4ADAMTS5MMP2MMP9 | |
| SCHEMBL9512738 | 0.80 | ALDH1A1 (0.57) | ARMMP13ADAMTS5MMP2POLB | |
| SCHEMBL1169469 | 0.78 | MAPT (0.49) | ARMMP2MMP1MMP9MMP14 | |
| SCHEMBL24242561 | 0.77 | ADAMTS4 (0.65) | ARADAMTS4MMP13ADAMTS5MMP2 | |
| SCHEMBL6325732 | 0.77 | ADAMTS4 (0.65) | ARADAMTS4MMP13ADAMTS5MMP2 | |
| SCHEMBL6325729 | 0.77 | ADAMTS4 (0.65) | ARADAMTS4MMP13ADAMTS5MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070037778-A1 | Therapy and prophylaxis of Alzheimer's Disease and Down's syndrome; inhibiting beta amyloid production; 2,4-difluoro-N-[(1S,2S)-1-(hydroxymethyl)-2-methylbutyl]benzenesulfonamide | WYETH (US) | 2007-02-15 | — | — | US | claimed |
| US-7166622-B2 | Substituted phenylsulfonamide inhibitors of beta amyloid production | WYETH (US) | 2007-01-23 | — | — | US | claimed |
| US-20040006050-A1 | Substituted phenylsulfonamide inhibitors of beta amyloid production | WYETH (US) | 2004-01-08 | — | — | US | claimed |
| US-20100120725-A1 | Substituted Phenylsulfonamide Inhibitors of Beta Amyloid Production | WYETH LLC (US) | 2010-05-13 | — | — | US | disclosed |
| US-7671075-B2 | Substituted phenylsulfonamide inhibitors of beta amyloid production | WYETH (US) | 2010-03-02 | — | — | US | disclosed |
| US-20070037778-A1 | Therapy and prophylaxis of Alzheimer's Disease and Down's syndrome; inhibiting beta amyloid production; 2,4-difluoro-N-[(1S,2S)-1-(hydroxymethyl)-2-methylbutyl]benzenesulfonamide | WYETH (US) | 2007-02-15 | — | — | US | disclosed |
| US-7166622-B2 | Substituted phenylsulfonamide inhibitors of beta amyloid production | WYETH (US) | 2007-01-23 | — | — | US | disclosed |
| US-20040006050-A1 | Substituted phenylsulfonamide inhibitors of beta amyloid production | WYETH (US) | 2004-01-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100120725-A1 | Substituted Phenylsulfonamide Inhibitors of Beta Amyloid Production | APP, BACE1, PSEN1 | AR 3289/4885BCL2L1 1596/4885MCL1 2822/4885 |
| US-20070037778-A1 | Therapy and prophylaxis of Alzheimer's Disease and Down's syndrome; inhibiting beta amyloid production; 2,4-difluoro-N-[(1S,2S)-1-(hydroxymethyl)-2-methylbutyl]benzenesulfonamide | BACE1, APP, PSEN1 | AR 2806/4885BCL2L1 872/4885MCL1 3072/4885 |
| US-20040006050-A1 | Substituted phenylsulfonamide inhibitors of beta amyloid production | APP, BACE1, PSEN1 | AR 3695/4885BCL2L1 1193/4885MCL1 2317/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.