SCHEMBL318840

SCHEMBL318840

COC(=O)c1ccc(C=C(C)C(N)=O)cc1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.58
GRIN2D O15399 1/20 0.53
GRIN3B O60391 1/20 0.53
GRIN1 Q05586 1/20 0.53
GRIN2A Q12879 1/20 0.53
GRIN2B Q13224 1/20 0.53
GRIN2C Q14957 1/20 0.53
GRIN3A Q8TCU5 1/20 0.53
MAPT P10636 5/20 0.49
CA1 P00915 3/20 0.48
CA2 P00918 3/20 0.48
TDP1 Q9NUW8 1/20 0.48
CA12 O43570 1/20 0.48
CA7 P43166 1/20 0.48
CA9 Q16790 1/20 0.48
CA14 Q9ULX7 1/20 0.48
PTPN1 P18031 1/20 0.47
LOXL2 Q9Y4K0 1/20 0.47
LMNA P02545 2/20 0.46
TSHR P16473 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL318839 1.00 ALDH1A1 (0.58) ALDH1A1GRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL5797759 0.84 ALDH1A1 (0.59) ALDH1A1GRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL8184665 0.84 ALDH1A1 (0.59) ALDH1A1GRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL5830527 0.83 AKR1C3 (0.52) ALDH1A1MAPTTDP1MEN1KMT2A
SCHEMBL5830531 0.83 AKR1C3 (0.52) ALDH1A1MAPTTDP1MEN1KMT2A
SCHEMBL2567047 0.82 LMNA (0.56) ALDH1A1MAPTCA1CA2TDP1
SCHEMBL2567045 0.82 LMNA (0.56) ALDH1A1MAPTCA1CA2TDP1
SCHEMBL8136582 0.82 NOS3 (0.47) ALDH1A1MAPTTDP1LMNAKMT2A
SCHEMBL7800031 0.82 NOS3 (0.47) ALDH1A1MAPTTDP1LMNAKMT2A
SCHEMBL4661723 0.82 ALDH1A1 (0.66) ALDH1A1GRIN2DGRIN3BGRIN1GRIN2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 87 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023094549-A1 FLEXIBLE PRESSURE-SENSITIVE ADHESIVES HAVING IMPROVED PROPERTIES WESTFÄLISCHE HOCHSCHULE GELSENKIRCHEN BOCHOLT RECKLINGHAUSEN (DE) 2023-06-01 WO disclosed
CN-114901653-A Novel amide derivatives useful as diacylglycerol acyltransferase 2 inhibitors and uses thereof 株式会社LG化学 2022-08-12 CN disclosed
US-10889146-B2 Tire object provided with an elastomer layer made of a thermoplastic elastomer in the form of an (A-b-(a-methylstyrene-co-B))n-b-C block copolymer COMPAGNIE GENERALE DES ETABLISSEMENTS MICHELIN (FR) 2021-01-12 US disclosed
CN-104812790-B Organopolysiloxane graft polymers 花王株式会社 2019-04-12 CN disclosed
EP-2927253-B1 ORGANOPOLYSILOXANE GRAFT POLYMER KAO CORP (JP) 2018-09-12 EP disclosed
US-10030131-B2 Pneumatic object provided with a gastight layer containing a thermoplastic elastomer and a thermoplastic COMPAGNIE GENERALE DES ETABLISSEMENTS MICHELIN (FR) 2018-07-24 US disclosed
EP-2791238-B1 TYRE PROVIDED WITH AN OUTER SIDEWALL COMPRISING A MIXTURE OF A DIENE ELASTOMER AND A THERMOPLASTIC ELASTOMER MICHELIN & CIE (FR) 2018-06-06 EP disclosed
EP-2791236-B1 TYRE PROVIDED WITH AN INNER LAYER COMPRISING A MIXTURE OF A DIENE ELASTOMER AND A THERMOPLASTIC ELASTOMER MICHELIN & CIE (FR) 2018-05-02 EP disclosed
US-9914328-B2 Inflatable object provided with a gas-tight layer containing a thermoplastic elastomer and a hydrocarbon-based resin COMPAGNIE GENERALE DES ETABLISSEMENTS MICHELIN (CH) 2018-03-13 US disclosed
US-20180043734-A1 TIRE OBJECT PROVIDED WITH AN ELASTOMER LAYER MADE OF A THERMOPLASTIC ELASTOMER IN THE FORM OF AN (A-B-(A-METHYLSTYRENE-CO-B))N-B-C BLOCK COPOLYMER COMPAGNIE GENERALE DES ETABLISSEMENTS MICHELIN (FR) 2018-02-15 US disclosed
EP-0907666-A1 PARTICLES COMPRISING AMPHIPHILIC COPOLYMERS, HAVING A CROSS-LINKED SHELL DOMAIN AND AN INTERIOR CORE DOMAIN, USEFUL FOR PHARMACEUTICAL AND OTHER APPLICATIONS G.D. Searle & Co. (US) 1999-04-14 EP disclosed
EP-0481333-B1 A silver halide color photographic material FUJI PHOTO FILM CO LTD (JP) 1998-08-12 EP disclosed
WO-1997049736-A2 PARTICLES COMPRISING AMPHIPHILIC COPOLYMERS, HAVING A CROSS-LINKED SHELL DOMAIN AND AN INTERIOR CORE DOMAIN, USEFUL FOR PHARMACEUTICAL AND OTHER APPLICATIONS G.D. SEARLE AND CO. (US) 1997-12-31 WO disclosed
WO-1997049387-A1 PARTICLES COMPRISING AMPHIPHILIC COPOLYMERS, HAVING A CROSS-LINKED SHELL DOMAIN AND AN INTERIOR CORE DOMAIN, USEFUL FOR PHARMACEUTICAL AND OTHER APPLICATIONS G.D. SEARLE AND CO. (US) 1997-12-31 WO disclosed
EP-0426043-B1 Silver halide color photographic material and method for forming color image FUJI PHOTO FILM CO LTD (JP) 1996-01-24 EP disclosed
US-5352571-A Having triazdopyrrole type cyan coupler and sparingly water soluble polymer FUJI PHOTO FILM CO., LTD. (JP) 1994-10-04 US disclosed
US-5264332-A Color print paper, improved formation of cyan dye image FUJI PHOTO FILM CO., LTD. (JP) 1993-11-23 US disclosed
EP-0481333-A1 A silver halide color photographic material Fuji Photo Film Co., Ltd. (JP) 1992-04-22 EP disclosed
US-5082764-A High boiling organic solven, cyan coupler, diffusion resistant substituted hydroquinone or benzoquinone FUJI PHOTO FILM CO., LTD. (JP) 1992-01-21 US disclosed
EP-0426043-A2 Silver halide color photographic material and method for forming color image Fuji Photo Film Co., Ltd. (JP) 1991-05-08 EP disclosed