Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | PNKP | Q96T60 | 1/20 | 0.34 |
| ▸ | ACP3 | P15309 | 1/20 | 0.34 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | CASR | P41180 | 1/20 | 0.34 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.33 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3188698 | 0.65 | HSD17B10 (0.43) | KMT2AMEN1ALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL5610075 | 0.65 | ALDH1A1 (0.61) | ALDH1A1CYP1A2CYP2C9CYP2C19ACP3 | |
| SCHEMBL29222050 | 0.64 | ACP3 (0.44) | KMT2AMEN1ALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL5608953 | 0.64 | ALDH1A1 (0.55) | KMT2AMEN1ALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL5608955 | 0.64 | ALDH1A1 (0.50) | KMT2AMEN1ALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL28337644 | 0.64 | ALDH1A1 (0.46) | KMT2AALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL7299447 | 0.64 | ALDH1A1 (0.46) | KMT2AALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL28337647 | 0.64 | ALDH1A1 (0.46) | KMT2AALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL9950214 | 0.62 | ALDH1A1 (0.62) | KMT2AALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL19514728 | 0.62 | ALDH1A1 (0.62) | KMT2AALDH1A1CYP1A2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7666904-B2 | 3-aryl-4-hydroxyfuranone compounds and the human and animal health use thereof | WYETH LLC (US) | 2010-02-23 | — | — | US | disclosed |
| US-7666904-B2 | 3-aryl-4-hydroxyfuranone compounds and the human and animal health use thereof | WYETH LLC (US) | 2010-02-23 | — | — | US | disclosed |
| US-7666904-B2 | 3-aryl-4-hydroxyfuranone compounds and the human and animal health use thereof | WYETH LLC (US) | 2010-02-23 | — | — | US | disclosed |
| US-7495027-B2 | 3-aryl-4-hydroxyfuranone compounds and the human and animal health use thereof | WYETH (US) | 2009-02-24 | — | — | US | disclosed |
| US-7495027-B2 | 3-aryl-4-hydroxyfuranone compounds and the human and animal health use thereof | WYETH (US) | 2009-02-24 | — | — | US | disclosed |
| US-7495027-B2 | 3-aryl-4-hydroxyfuranone compounds and the human and animal health use thereof | WYETH (US) | 2009-02-24 | — | — | US | disclosed |
| US-20090036439-A1 | 3-ARYL-4-HYDROXYFURANONE COMPOUNDS AND THE HUMAN AND ANIMAL HEALTH USE THEREOF | WYETH (US) | 2009-02-05 | — | — | US | disclosed |
| US-20090036439-A1 | 3-ARYL-4-HYDROXYFURANONE COMPOUNDS AND THE HUMAN AND ANIMAL HEALTH USE THEREOF | WYETH (US) | 2009-02-05 | — | — | US | disclosed |
| US-20090036439-A1 | 3-ARYL-4-HYDROXYFURANONE COMPOUNDS AND THE HUMAN AND ANIMAL HEALTH USE THEREOF | WYETH (US) | 2009-02-05 | — | — | US | disclosed |
| EP-1654244-A1 | 3-ARYL-4-HYDROXYFURANONE COMPOUNDS AND PHARMACEUTICAL AND VETERINARY COMPOSITIONS CONTAINING THEM | Wyeth (US) | 2006-05-10 | — | — | EP | disclosed |
| US-20050054721-A1 | 3-Aryl-4-Hydroxyfuranone compounds and the human and animal health use thereof | WYETH (US) | 2005-03-10 | — | — | US | disclosed |
| WO-2005019196-A1 | 3-ARYL-4-HYDROXYFURANONE COMPOUNDS AND PHARMACEUTICAL AND VETERINARY COMPOSITIONS CONTAINING THEM | WYETH (US) | 2005-03-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050054721-A1 | 3-Aryl-4-Hydroxyfuranone compounds and the human and animal health use thereof | FUCA1, PGLS, HSD17B14 | KMT2A 4285/4885MEN1 2296/4885ALDH1A1 1161/4885 |
| US-20090036439-A1 | 3-ARYL-4-HYDROXYFURANONE COMPOUNDS AND THE HUMAN AND ANIMAL HEALTH USE THEREOF | FUCA1, PGLS, HSD17B14 | KMT2A 4285/4885MEN1 2296/4885ALDH1A1 1161/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.