Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.44 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.42 |
| ▸ | AXL | P30530 | 2/20 | 0.42 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.42 |
| ▸ | PLK4 | O00444 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | ROS1 | P08922 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | FRK | P42685 | 1/20 | 0.42 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.42 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.42 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.42 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.42 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1340669 | 0.81 | KDM4E (0.53) | KDM4EALDH1A1MAPTCYP3A4ALOX15 | |
| SCHEMBL2057011 | 0.81 | KMO (0.52) | MEN1KDM4EALDH1A1MAPTKMT2A | |
| SCHEMBL10419666 | 0.78 | KDM4E (0.50) | KDM4EALDH1A1MAPTCYP3A4ALOX15 | |
| SCHEMBL25779251 | 0.77 | PIN1 (0.53) | — | |
| SCHEMBL1965244 | 0.77 | PIN1 (0.54) | CSNK2A2CSNK2BKDM4EALDH1A1MAPT | |
| SCHEMBL3345499 | 0.77 | KMO (0.56) | MEN1KDM4EALDH1A1CYP3A4ATM | |
| SCHEMBL25779250 | 0.73 | MKNK1 (0.53) | MKNK2PIM1MKNK1KDM4EALDH1A1 | |
| SCHEMBL27580202 | 0.73 | MAP4K4 (0.47) | MAOAMAP4K4AXLMKNK2MEN1 | |
| SCHEMBL984761 | 0.72 | MCL1 (0.46) | MCL1AURKBMEN1KDM4EALDH1A1 | |
| SCHEMBL27634866 | 0.72 | ADRB2 (0.44) | KDM4EALDH1A1MAPTCYP3A4ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2590968-A1 | CYCLIC ETHER COMPOUNDS USEFUL AS KINASE INHIBITORS | Novartis AG (CH) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012004217-A1 | CYCLIC ETHER COMPOUNDS USEFUL AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2012-01-12 | — | — | WO | disclosed |