Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.68 |
| ▸ | LMNA | P02545 | 2/20 | 0.68 |
| ▸ | MEN1 | O00255 | 1/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.68 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.63 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.63 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.63 |
| ▸ | NPY2R | P49146 | 6/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3195392 | 1.00 | KMT2A (0.68) | KMT2ALMNAMEN1ALDH1A1OPRM1 | |
| SCHEMBL10862008 | 0.86 | KMT2A (0.71) | KMT2ALMNAMEN1ALDH1A1OPRM1 | |
| SCHEMBL7657250 | 0.83 | LMNA (0.94) | KMT2ALMNAMEN1ALDH1A1OPRM1 | |
| SCHEMBL31652566 | 0.82 | KMT2A (0.66) | KMT2ALMNAMEN1ALDH1A1OPRM1 | |
| SCHEMBL31652444 | 0.82 | KMT2A (0.66) | KMT2ALMNAMEN1ALDH1A1OPRM1 | |
| SCHEMBL2789416 | 0.82 | LMNA (0.97) | KMT2ALMNAMEN1ALDH1A1OPRM1 | |
| SCHEMBL1819794 | 0.82 | LMNA (0.97) | KMT2ALMNAMEN1ALDH1A1OPRM1 | |
| SCHEMBL6663882 | 0.81 | KMT2A (0.73) | KMT2ALMNAMEN1ALDH1A1OPRM1 | |
| Hydrochloric Acid SCHEMBL5606289 | 0.81 | LMNA (1.00) | KMT2ALMNAMEN1ALDH1A1OPRM1 | |
| SCHEMBL11384579 | 0.80 | LMNA (0.62) | KMT2ALMNAMEN1ALDH1A1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029536-B1 | BICYCLIC TETRAHYDROPYRROLE COMPOUNDS | ESTEVE LABOR DR (ES) | 2013-08-28 | — | — | EP | disclosed |
| US-8299113-B2 | Bicyclic tetrahydropyrrole compounds | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2012-10-30 | — | — | US | disclosed |
| US-8299113-B2 | Bicyclic tetrahydropyrrole compounds | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2012-10-30 | — | — | US | disclosed |
| US-8299113-B2 | Bicyclic tetrahydropyrrole compounds | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2012-10-30 | — | — | US | disclosed |
| US-20100029738-A1 | Bicyclic Tetrahydropyrrole Compounds | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2010-02-04 | — | — | US | disclosed |
| US-20100029738-A1 | Bicyclic Tetrahydropyrrole Compounds | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2010-02-04 | — | — | US | disclosed |
| US-20100029738-A1 | Bicyclic Tetrahydropyrrole Compounds | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2010-02-04 | — | — | US | disclosed |
| EP-2029536-A1 | BICYCLIC TETRAHYDROPYRROLE COMPOUNDS | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007128458-A1 | BICYCLIC TETRAHYDROPYRROLE COMPOUNDS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2007-11-15 | — | — | WO | disclosed |
| WO-2007128458-A1 | BICYCLIC TETRAHYDROPYRROLE COMPOUNDS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2007-11-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029738-A1 | Bicyclic Tetrahydropyrrole Compounds | CYP11B2, CYP11B1, SDHA | KMT2A 3710/4885LMNA 2795/4885MEN1 1305/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.