Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | GPR183 | P32249 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | ACACB | O00763 | 4/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15673630 | 0.94 | GPR119 (0.48) | GPR119USP2SMN1; SMN2SCD5GPR183 | |
| SCHEMBL15673657 | 0.91 | USP2 (0.38) | GPR119USP2SMN1; SMN2GPR183GRM5 | |
| SCHEMBL15673214 | 0.84 | SCD5 (0.44) | GPR119SCD5CYP11B2GPR183ATM | |
| SCHEMBL138482 | 0.83 | — | — | |
| SCHEMBL326350 | 0.82 | GRM5 (0.54) | GPR119SCD5CYP11B2GPR183GRM5 | |
| SCHEMBL320350 | 0.80 | GPR119 (0.42) | GPR119SCD5CYP11B2GPR183GRM5 | |
| SCHEMBL12050570 | 0.80 | GPR119 (0.45) | GPR119USP2SMN1; SMN2SCD5CYP11B2 | |
| SCHEMBL12901472 | 0.80 | GPR119 (0.45) | GPR119USP2SMN1; SMN2SCD5CYP11B2 | |
| SCHEMBL12901473 | 0.80 | GPR119 (0.45) | GPR119USP2SMN1; SMN2SCD5CYP11B2 | |
| SCHEMBL12901445 | 0.80 | GPR119 (0.45) | GPR119USP2SMN1; SMN2SCD5CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2590985-A1 | NOVEL SPIROHETEROCYCLIC COMPOUNDS AS MGLU5 ANTAGONISTS | Recordati Ireland Limited (IE) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012004400-A1 | NOVEL SPIROHETEROCYCLIC COMPOUNDS AS MGLU5 ANTAGONISTS | RECORDATI IRELAND LIMITED (IE) | 2012-01-12 | — | — | WO | disclosed |