Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | PRKDC | P78527 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.45 |
| ▸ | TUBB | P07437 | 2/20 | 0.45 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.45 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.45 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.45 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.45 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.45 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.45 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.45 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.45 |
| ▸ | TUBA1A | Q71U36 | 2/20 | 0.45 |
| ▸ | TUBA1C | Q9BQE3 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28424719 | 0.84 | TDP1 (0.40) | ALDH1A1TDP1MAPTCYP3A4KDM4E | |
| SCHEMBL6233733 | 0.84 | ALDH1A1 (0.41) | ALDH1A1TDP1MAPTCYP3A4KDM4E | |
| SCHEMBL6815698 | 0.84 | HTT (0.35) | ALDH1A1TDP1MAPTCYP3A4KDM4E | |
| SCHEMBL1356676 | 0.81 | ALDH1A1 (0.47) | ALDH1A1TDP1MAPTCYP3A4KDM4E | |
| SCHEMBL28383967 | 0.80 | ALDH1A1 (0.41) | ALDH1A1TDP1MAPTCYP3A4KDM4E | |
| SCHEMBL17339128 | 0.79 | TDP1 (0.42) | ALDH1A1TDP1MAPTCYP3A4KDM4E | |
| SCHEMBL10778338 | 0.78 | ALDH1A1 (0.62) | ALDH1A1TDP1MAPTCYP3A4KDM4E | |
| SCHEMBL9007951 | 0.77 | ALDH1A1 (0.54) | ALDH1A1TDP1MAPTCYP3A4KDM4E | |
| SCHEMBL8426114 | 0.77 | VCAM1 (0.40) | ALDH1A1TDP1MAPTCYP3A4KDM4E | |
| SCHEMBL10326054 | 0.76 | ALDH1A1 (0.57) | ALDH1A1TDP1MAPTCYP3A4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 117 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1648886-B1 | BENZOXAZINONE-DERIVED SULFONAMIDE COMPOUNDS, THEIR PREPARATION AND USE AS MEDICAMENTS | ESTEVE LABOR DR (ES) | 2009-12-09 | — | — | EP | claimed |
| US-20070032482-A1 | Benzoxazinone-derived sulfonamide compounds, their preparation and use as medicaments | LABORATORIOS DEL DR. ESTEVE S.A. (ES) | 2007-02-08 | — | — | US | claimed |
| EP-1648886-A1 | BENZOXAZINONE-DERIVED SULFONAMIDE COMPOUNDS, THEIR PREPARATION AND USE AS MEDICAMENTS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2006-04-26 | — | — | EP | claimed |
| WO-2005014589-A1 | BENZOXAZINONE-DERIVED SULFONAMIDE COMPOUNDS, THEIR PREPARATION AND USE AS MEDICAMENTS | LABORATORIOS DEL DR. ESTEVE S.A. (DE) | 2005-02-17 | — | — | WO | claimed |
| US-6756370-B1 | POTENT 5-HT2A RECEPTOR ANTAGONISTS | MERCK PATENT GMBH (DE) | 2004-06-29 | — | — | US | claimed |
| US-11803122-B2 | Chemical amplification-type photosensitive composition, photosensitive dry film, production method of patterned resist layer, production method of plated molded article, compound, and production method of compound | TOKYO OHKA KOGYO CO., LTD. (JP) | 2023-10-31 | — | — | US | disclosed |
| US-20210356863-A1 | CHEMICAL AMPLIFICATION-TYPE PHOTOSENSITIVE COMPOSITION, PHOTOSENSITIVE DRY FILM, PRODUCTION METHOD OF PATTERNED RESIST LAYER, PRODUCTION METHOD OF PLATED MOLDED ARTICLE, COMPOUND, AND PRODUCTION METHOD OF COMPOUND | TOKYO OHKA KOGYO CO., LTD. (JP) | 2021-11-18 | — | — | US | disclosed |
| EP-2121649-B1 | Method for the production of benzofuran-2-carboxamides | MERCK PATENT GMBH (DE) | 2013-02-27 | — | — | EP | disclosed |
| CN-101573347-B | Process for preparing benzofuran-2-carboxamides | MERCK PATENT GMBH | 2012-10-10 | — | — | CN | disclosed |
| US-20120128768-A1 | ACTIVE SUBSTANCE COMBINATION COMPRISING A COMPOUND WITH NPY RECEPTOR AFFINITY AND A COMPOUND WITH 5-HT6 RECEPTOR AFFINITY | LABORATORIOS DEL DR. ESTEVE S.A (ES) | 2012-05-24 | — | — | US | disclosed |
| US-7741343-B2 | 6H-oxazolo[4,5 e]indole derivatives as nicotinic acetylcholine receptor ligands and/or serotonergic ligands | MERCK PATENT GMBH (DE) | 2010-06-22 | — | — | US | disclosed |
| US-20100036139-A1 | PROCESS FOR THE PREPARATION OF BENZOFURAN-2-CARBOXAMIDES | MERCK PATENT GMBH (DE) | 2010-02-11 | — | — | US | disclosed |
| EP-0755934-A1 | Endothelin receptor antagonists | MERCK PATENT GmbH (DE) | 1997-01-29 | — | — | EP | disclosed |
| EP-0476457-B1 | 2-Benzothiazolyl tetrazolium salt indicators | BAYER AG (US) | 1996-12-04 | — | — | EP | disclosed |
| EP-0476454-B1 | Analytical method using tetrazolium salt indicators having a reflectance plateau | BAYER AG (US) | 1996-10-23 | — | — | EP | disclosed |
| EP-0733626-A1 | N-(Benzofuranazyl)-arylsulphonamides and their analogues useful as endothelin-receptor-antagonists | MERCK PATENT GmbH (DE) | 1996-09-25 | — | — | EP | disclosed |
| US-5300637-A | Useful in determination of reducing substances | MILES INC. (US) | 1994-04-05 | — | — | US | disclosed |
| US-5126275-A | Chromogenic reducing indicators for reducing substances such as NADH | MILES INC. (US) | 1992-06-30 | — | — | US | disclosed |
| US-4156086-A | INTERMEDIATES FOR AZO DYES | BAYER AKTIENGESELLSCHAFT (DE) | 1979-05-22 | — | — | US | disclosed |
| US-4038268-A | DIAZOTIZATION, COUPLING | BAYER AKTIENGESELLSCHAFT (DT) | 1977-07-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070032482-A1 | Benzoxazinone-derived sulfonamide compounds, their preparation and use as medicaments | HTR6, HTR5A, P2RX6 | ALDH1A1 1597/4885TDP1 3265/4885MAPT 4220/4885 |
| US-20100036139-A1 | PROCESS FOR THE PREPARATION OF BENZOFURAN-2-CARBOXAMIDES | CCNT1, CCNT2, CBR1 | ALDH1A1 396/4885TDP1 2004/4885MAPT 2936/4885 |
| US-20120128768-A1 | ACTIVE SUBSTANCE COMBINATION COMPRISING A COMPOUND WITH NPY RECEPTOR AFFINITY AND A COMPOUND WITH 5-HT6 RECEPTOR AFFINITY | HTR6, NPY5R, NPY2R | ALDH1A1 3499/4885TDP1 3996/4885MAPT 2467/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.