Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 2/20 | 0.33 |
| ▸ | GPR27 | Q9NS67 | 3/20 | 0.32 |
| ▸ | RORC | P51449 | 1/20 | 0.32 |
| ▸ | PYGL | P06737 | 1/20 | 0.31 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 2/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.31 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.31 |
| ▸ | IDH1 | O75874 | 1/20 | 0.31 |
| ▸ | SGK1 | O00141 | 2/20 | 0.31 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.30 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.30 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.30 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.30 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.30 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1745697 | 0.90 | SLC1A3 (0.35) | SMN1; SMN2CA2PIK3CDPIK3CGCDK5 | |
| SCHEMBL326998 | 0.74 | PIK3CD (0.33) | SMN1; SMN2GPR27PIK3CDPIK3CGPIK3C3 | |
| SCHEMBL29668968 | 0.74 | CNR2 (0.32) | SMN1; SMN2SGK1 | |
| SCHEMBL16094686 | 0.74 | ALPL (0.35) | ABL1 | |
| SCHEMBL27174917 | 0.72 | PHGDH (0.38) | RORCCA2CDK5CDK5R1CCNA2 | |
| SCHEMBL17675158 | 0.70 | CA1 (0.41) | SMN1; SMN2CA2PIK3CDPIK3CGCDK5 | |
| SCHEMBL1094850 | 0.63 | PIK3CD (0.33) | CA2PIK3CDPIK3CGCA1 | |
| SCHEMBL13646656 | 0.62 | ALDH1A1 (0.33) | PTPN22CA2SGK1CA1 | |
| SCHEMBL29641997 | 0.62 | ALDH1A1 (0.33) | PTPN22CA2SGK1CA1 | |
| SCHEMBL320178 | 0.61 | SCN8A (0.36) | PTPN22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2590972-A2 | CHEMICAL COMPOUNDS | Pfizer Limited (GB) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012004706-A2 | CHEMICAL COMPOUNDS | PFIZER LIMITED (GB) | 2012-01-12 | — | — | WO | disclosed |