Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.30 |
| ▸ | ANPEP | P15144 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6597204 | 0.80 | ALDH1A1 (0.44) | KMT2AALDH1A1 | |
| SCHEMBL9878900 | 0.78 | HTT (0.32) | — | |
| SCHEMBL11103860 | 0.77 | KMT2A (0.31) | KMT2ACYP1A2ALDH1A1CYP2C19 | |
| SCHEMBL11107504 | 0.77 | CYP1A2 (0.36) | KMT2ACYP1A2HIF1AALDH1A1BRD4 | |
| SCHEMBL8492515 | 0.77 | KMT2A (0.34) | KMT2ACYP1A2HIF1AALDH1A1BRD4 | |
| SCHEMBL11108940 | 0.74 | GAA (0.36) | KMT2ACYP1A2HIF1AALDH1A1 | |
| SCHEMBL3969985 | 0.72 | CYP1A2 (0.38) | KMT2ACYP1A2HIF1ABRD4 | |
| SCHEMBL11266227 | 0.72 | POLB (0.43) | KMT2ACYP1A2ALDH1A1CYP2C19 | |
| SCHEMBL11105927 | 0.72 | GAA (0.39) | KMT2AALDH1A1 | |
| SCHEMBL3970077 | 0.70 | KMT2A (0.35) | KMT2ACYP1A2HIF1ABRD4MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119684257-A | Preparation method of 4-amino-5-methylthiophene-3-carboxylic acid methyl ester | 阜新睿光氟化学有限公司 | 2025-03-25 | — | — | CN | claimed |
| CN-111732568-B | Synthetic method of 4-methoxycarbonyl-2-methylthiophene-3-sulfonyl chloride | 北京怡力生物科技有限公司 | 2022-07-26 | — | — | CN | claimed |
| CN-111732568-A | Synthesis method of 4-methoxycarbonyl-2-methylthiophene-3-sulfonyl chloride | 北京怡力生物科技有限公司 | 2020-10-02 | — | — | CN | claimed |
| CN-120035585-A | Process for the preparation of substituted aminothiophenes | 安道麦阿甘有限公司 | 2025-05-23 | — | — | CN | disclosed |
| CN-119684257-A | Preparation method of 4-amino-5-methylthiophene-3-carboxylic acid methyl ester | 阜新睿光氟化学有限公司 | 2025-03-25 | — | — | CN | disclosed |
| CN-111732568-B | Synthetic method of 4-methoxycarbonyl-2-methylthiophene-3-sulfonyl chloride | 北京怡力生物科技有限公司 | 2022-07-26 | — | — | CN | disclosed |
| CN-111732568-B | Synthetic method of 4-methoxycarbonyl-2-methylthiophene-3-sulfonyl chloride | 北京怡力生物科技有限公司 | 2022-07-26 | — | — | CN | disclosed |
| CN-111732568-A | Synthesis method of 4-methoxycarbonyl-2-methylthiophene-3-sulfonyl chloride | 北京怡力生物科技有限公司 | 2020-10-02 | — | — | CN | disclosed |
| EP-2763985-B1 | {(4-(4-MORPHOLINO-DIHYDROTHIENO[3,4-D]PYRIMIDIN-2-YL)ARYL}UREA OR CARBAMATE DERIVATIVES AS MTOR INHIBITORS | CELLZOME LTD (GB) | 2016-06-22 | — | — | EP | disclosed |
| EP-2763985-B1 | {(4-(4-MORPHOLINO-DIHYDROTHIENO[3,4-D]PYRIMIDIN-2-YL)ARYL}UREA OR CARBAMATE DERIVATIVES AS MTOR INHIBITORS | CELLZOME LTD (GB) | 2016-06-22 | — | — | EP | disclosed |
| US-9242993-B2 | Morpholino substituted bicyclic pyrimidine urea or carbamate derivatives as mTOR inhibitors | CELLZOME LIMITED (GB) | 2016-01-26 | — | — | US | disclosed |
| US-7642221-B2 | herbicides; preparation from chemical intermediates; treating the crops | BAYER AKTIENGESELLSCHAFT (DE) | 2010-01-05 | — | — | US | disclosed |
| US-6964939-B1 | Substituted thiene-3-yl-sulfonyl amino(thio)carbonyl-triazolin(thi)ones | BAYER AKTIENGESELLSCHAFT (DE) | 2005-11-15 | — | — | US | disclosed |
| US-20050130843-A1 | Substituted thien-3-yl-sulphonylamino(thio)carbonyl-triazolin(ethi)ones | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2005-06-16 | — | — | US | disclosed |
| EP-0371594-B1 | Thiophene-carboxamide derivatives and their pharmaceutical use | LILLY SA (ES) | 1994-02-16 | — | — | EP | disclosed |
| US-5015656-A | Antidepressants, anxiolytic compounds, central nervous system active compounds for psychotic conditions, aminoalkylcarboxami de derivatives of thiophene | LILLY S.A. (ES) | 1991-05-14 | — | — | US | disclosed |
| EP-0371594-A1 | Thiophene-carboxamide derivatives and their pharmaceutical use | LILLY S.A. (ES) | 1990-06-06 | — | — | EP | disclosed |
| US-4428963-A | ANTILIPEMIC, ANTIOBESITY | HOFFMANN-LA ROCHE INC. (US) | 1984-01-31 | — | — | US | disclosed |
| US-4317915-A | ANTILIPEMIC, ANTIOBESITY | HOFFMANN-LA ROCHE INC. (US) | 1982-03-02 | — | — | US | disclosed |
| US-4272507-A | Phenylaminothiophenacetic acids, their synthesis, compositions and use | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1981-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050130843-A1 | Substituted thien-3-yl-sulphonylamino(thio)carbonyl-triazolin(ethi)ones | TST, SULT1E1, SULT2A1 | KMT2A 1327/4885CYP1A2 35/4885HIF1A 3401/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.