SCHEMBL3199856

SCHEMBL3199856

CN1CCc2nc(C(=O)NC3CC(O)CCC3NC(=O)c3cc4cc(Cl)ccc4[nH]3)sc2C1

nearest known ligand 0.89

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
F10 P00742 20/20 0.89
F2 P00734 4/20 0.84

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3193226 1.00 F10 (0.89) F10F2
SCHEMBL2939989 1.00 F10 (0.89) F10F2
SCHEMBL2940319 1.00 F10 (0.89) F10F2
SCHEMBL4098623 0.95 F10 (0.92) F10F2
SCHEMBL4098626 0.95 F10 (0.92) F10F2
SCHEMBL10476703 0.95 F10 (0.92) F10F2
SCHEMBL12631576 0.94 F10 (1.00) F10F2
SCHEMBL12036012 0.94 F10 (1.00) F10F2
SCHEMBL13413153 0.94 F10 (0.89) F10F2
SCHEMBL12761575 0.94 F10 (0.89) F10F2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2266991-A2 Process for producing thiazole derivative Daiichi Sankyo Company, Limited (JP) 2010-12-29 EP disclosed
EP-2266992-A2 Process for producing thiazole derivative Daiichi Sankyo Company, Limited (JP) 2010-12-29 EP disclosed
US-20100076192-A1 PROCESS FOR PRODUCING 5-METHYL-4,5,6,7-TETRAHYDROTHIAZOLO[5,4-c]PYRIDINE-2-CARBOXYLIC ACID DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2010-03-25 US disclosed
US-7678910-B2 Process for producing 5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]Pyridine-2-carboxylic acid DAIICHI SANKYO COMPANY, LIMITED (JP) 2010-03-16 US disclosed
US-20090192313-A1 PROCESS FOR PRODUCING 5-METHYL-4,5,6,7-TETRAHYDROTHIAZOLO[5,4-c]PYRIDINE-2-CARBOXYLIC ACID DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2009-07-30 US disclosed
US-7547786-B2 5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid; intermediate for compound which exhibits an inhibitory action on an activated coagulation factor X, and which is thus useful as a preventive/therapeutic drug for thrombus-related diseases DAIICHI SANKYO COMPANY, LIMITED (JP) 2009-06-16 US disclosed
US-20070135476-A1 Process for producing thiazole derivative DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2007-06-14 US disclosed
EP-1683800-A1 PROCESS FOR PRODUCING THIAZOLE DERIVATIVE DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2006-07-26 EP disclosed
EP-1415992-A1 DIAMINE DERIVATIVES DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2004-05-06 EP disclosed
EP-1405852-A1 DIAMINE DERIVATIVES DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2004-04-07 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100076192-A1 PROCESS FOR PRODUCING 5-METHYL-4,5,6,7-TETRAHYDROTHIAZOLO[5,4-c]PYRIDINE-2-CARBOXYLIC ACID NOX4, NOX5, NOS2 F10 1072/4885F2 1340/4885
US-20090192313-A1 PROCESS FOR PRODUCING 5-METHYL-4,5,6,7-TETRAHYDROTHIAZOLO[5,4-c]PYRIDINE-2-CARBOXYLIC ACID PAH, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, IL4 F10 388/4885F2 1156/4885
US-20070135476-A1 Process for producing thiazole derivative TALDO1, CYP3A4, DHPS F10 4433/4885F2 3542/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.