Glabranin

Glabranin

SCHEMBL320136

CC(C)=CCc1c(O)cc(O)c2c1O[C@H](c1ccccc1)CC2=O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 1/20 1.00
CYP2D6 P10635 1/20 1.00
CYP2C9 P11712 1/20 1.00
ACHE P22303 1/20 1.00
CYP2C19 P33261 1/20 1.00
ABCG2 Q9UNQ0 5/20 0.83
ESR1 P03372 5/20 0.83
ESR2 Q92731 3/20 0.83
CACNA1H O95180 3/20 0.83
AKR1B10 O60218 2/20 0.83
AKR1B1 P15121 2/20 0.83
CACNA1G O43497 2/20 0.83
MAOA P21397 1/20 0.83
PDE5A O76074 1/20 0.83
CYP19A1 P11511 1/20 0.77
PTPN1 P18031 1/20 0.75
PDPK1 O15530 1/20 0.68
PRKCA P17252 1/20 0.68
BACE1 P56817 1/20 0.68
PRKCQ Q04759 1/20 0.68

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Glabranin SCHEMBL320135 1.00 CYP3A4 (1.00) CYP3A4CYP2D6CYP2C9ACHECYP2C19
Sophoraflavanone B SCHEMBL147316 0.91 ESR1 (1.00) CYP3A4CYP2D6CYP2C9ACHECYP2C19
Sophoraflavanone B SCHEMBL29396586 0.91 ESR1 (1.00) CYP3A4CYP2D6CYP2C9ACHECYP2C19
Sophoraflavanone B SCHEMBL1171435 0.91 ESR1 (1.00) CYP3A4CYP2D6CYP2C9ACHECYP2C19
Sophoraflavanone B SCHEMBL14304885 0.91 ESR1 (1.00) CYP3A4CYP2D6CYP2C9ACHECYP2C19
Sophoraflavanone B SCHEMBL1931652 0.90 ESR1 (0.98) CYP3A4CYP2D6CYP2C9ACHECYP2C19
SCHEMBL29895534 0.88 CYP3A4 (0.79) CYP3A4CYP2D6CYP2C9ACHECYP2C19
SCHEMBL1170921 0.88 PTPN1 (0.84) CYP3A4CYP2D6CYP2C9ACHECYP2C19
SCHEMBL24075554 0.86 MAPT (0.83) CYP3A4CYP2D6CYP2C9ACHECYP2C19
Lespedezaflavanone B SCHEMBL1171210 0.86 PTPN1 (1.00) CYP3A4CYP2D6CYP2C9ACHECYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 124 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240373850-A1 Compositions comprising resinous exudate metabolites from plants of the genus Adesmia, used to control and treat infections in plant crops; and methods for controlling infections in plant crops. PONTIFICIA UNIV CATOLICA DE VALPARAISO (CL) 2024-11-14 US claimed
WO-2022221968-A1 COMPOSITIONS COMPRISING RESINOUS EXUDATE METABOLITES FROM PLANTS OF THE GENUS ADESMIA, USED TO CONTROL AND TREAT INFECTIONS IN PLANT CROPS; AND METHODS FOR CONTROLLING INFECTIONS IN PLANT CROPS PONTIFICIA UNIVERSIDAD CATÓLICA DE VALPARAÍSO (CL) 2022-10-27 WO claimed
CN-114245826-A Method for producing strictoside and monoterpene indole alkaloid 丹麦科技大学 2022-03-25 CN claimed
US-11234918-B2 Methods for botanical and/or algae extraction BASF CORPORATION (US) 2022-02-01 US claimed
CN-112135829-A Method and apparatus for preparing terpene indole alkaloid 约翰·英尼斯中心 2020-12-25 CN claimed
CN-111714489-A Double-topoisomerase inhibitor with tumor killing effect and preparation method thereof 德萌达生物医药科技(杭州)有限公司 2020-09-29 CN claimed
EP-2858641-B1 IMPROVED METHODS FOR BOTANICAL AND/OR ALGAE EXTRACTION BASF CORP (US) 2017-09-06 EP claimed
CN-106728142-A A kind of pharmaceutical composition for treating optic atrophy 济南昊雨青田医药技术有限公司 2017-05-31 CN claimed
CN-106727859-A It is a kind of to treat pharmaceutical composition of pharyngitis and preparation method thereof 济南昊雨青田医药技术有限公司 2017-05-31 CN claimed
CN-106727877-A It is a kind of to treat pharmaceutical composition of periodontitis and preparation method thereof 济南昊雨青田医药技术有限公司 2017-05-31 CN claimed
US-20150140141-A1 METHODS FOR BOTANICAL AND/OR ALGAE EXTRACTION BASF BEAUTY CARE SOLUTIONS FRANCE SAS (FR) 2015-05-21 US claimed
EP-2858641-A1 IMPROVED METHODS FOR BOTANICAL AND/OR ALGAE EXTRACTION BASF Corporation (US) 2015-04-15 EP claimed
WO-2013184884-A1 IMPROVED METHODS FOR BOTANICAL AND/OR ALGAE EXTRACTION BASF CORPORATION (US) 2013-12-12 WO claimed
EP-2590624-A1 USE OF GLABRANIN FOR STIMULATING HAIR GROWTH Unilever PLC (GB) 2013-05-15 EP claimed
US-20130096189-A1 USE OF GLABRANIN FOR STIMULATING HAIR GROWTH CONOPCO, INC., D/B/A UNILEVER 2013-04-18 US claimed
CN-102985065-A Use of glabranin for stimulating hair growth UNILEVER PL 2013-03-20 CN claimed
WO-2012004228-A1 USE OF GLABRANIN FOR STIMULATING HAIR GROWTH UNILEVER PLC (GB) 2012-01-12 WO claimed
US-20030082101-A1 Accelerators for increasing the rate of formation of free radicals and reactive oxygen species CAVALIER DISCOVERY 2003-05-01 US claimed
WO-2002100478-A9 ACCELERATORS FOR INCREASING THE RATE OF FORMATION OF FREE RADICALS AND REACTIVE OXYGEN SPECIES CAVALIER DISCOVERY (US) 2003-03-27 WO claimed
WO-2002100478-A2 ACCELERATORS FOR INCREASING THE RATE OF FORMATION OF FREE RADICALS AND REACTIVE OXYGEN SPECIES CAVALIER DISCOVERY (US) 2002-12-19 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11234918-B2 Methods for botanical and/or algae extraction ALG1, ALG8, CUTA CYP3A4 3724/4885CYP2D6 3555/4885CYP2C9 2132/4885
US-20030082101-A1 Accelerators for increasing the rate of formation of free radicals and reactive oxygen species SOD1, SOD3, APEX1 CYP3A4 1097/4885CYP2D6 762/4885CYP2C9 2785/4885
US-20130096189-A1 USE OF GLABRANIN FOR STIMULATING HAIR GROWTH GALR2, GALR1, GALR3 CYP3A4 4524/4885CYP2D6 3533/4885CYP2C9 3016/4885
US-20240373850-A1 Compositions comprising resinous exudate metabolites from plants of the genus Adesmia, used to control and treat infections in plant crops; and methods for controlling infections in plant crops. ERG28, RXFP4, CROCC CYP3A4 1006/4885CYP2D6 1060/4885CYP2C9 2998/4885
US-20150140141-A1 METHODS FOR BOTANICAL AND/OR ALGAE EXTRACTION ALG1, ALG8, CUTA CYP3A4 3724/4885CYP2D6 3555/4885CYP2C9 2132/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.