SCHEMBL3201695

SCHEMBL3201695

Clc1cc(Cl)c(Cl)c(-c2ncccn2)c1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.46
SCN2A Q99250 4/20 0.43
SCN9A Q15858 2/20 0.39
SCN3A Q9NY46 2/20 0.39
SCN10A Q9Y5Y9 2/20 0.39
AHR P35869 3/20 0.38
HPGD P15428 1/20 0.38
TSHR P16473 1/20 0.38
HSD17B10 Q99714 1/20 0.38
CYP3A4 P08684 1/20 0.36
CCR1 P32246 2/20 0.35
CCR8 P51685 2/20 0.35
CCR5 P51681 1/20 0.35
NOTUM Q6P988 1/20 0.35
CYP19A1 P11511 1/20 0.34
GRM5 P41594 1/20 0.34
KCNK2 O95069 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.33
CNR2 P34972 1/20 0.33
HPGDS O60760 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2458581 0.79 SMN1; SMN2 (0.38) ALDH1A1HPGDTSHRHSD17B10CYP3A4
SCHEMBL5740853 0.77 ALDH1A1 (0.41) ALDH1A1AHRTSHRHSD17B10CYP3A4
SCHEMBL2666281 0.76 L3MBTL1 (0.40) ALDH1A1SCN2ASCN9ASCN3ASCN10A
SCHEMBL2930780 0.75 ALDH1A1 (0.69) ALDH1A1SCN2ASCN9ASCN3ASCN10A
SCHEMBL3453300 0.74 GRM5 (0.51) ALDH1A1AHRHPGDTSHRHSD17B10
SCHEMBL6439475 0.71 CNR2 (0.50) SCN2ASCN9ASCN3ASCN10ATSHR
SCHEMBL3425873 0.71 CES1 (0.34) HPGDCYP3A4CCR1CCR8CCR5
SCHEMBL4459668 0.71 ALDH1A1 (0.61) ALDH1A1SCN2AAHRHPGDTSHR
SCHEMBL4451811 0.69 ALDH1A1 (0.58) ALDH1A1SCN2AAHRHPGDTSHR
SCHEMBL4459067 0.69 ALDH1A1 (0.58) ALDH1A1SCN2AAHRHPGDTSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20100029613-A1 TREATMENT AND PREVENTION OF EPILEPSY UNIVERSITY OF ROCHESTER (US) 2010-02-04 US disclosed