Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 8/20 | 0.55 |
| ▸ | FPR2 | P25090 | 5/20 | 0.45 |
| ▸ | PROKR1 | Q8TCW9 | 5/20 | 0.45 |
| ▸ | PFKFB3 | Q16875 | 4/20 | 0.43 |
| ▸ | PFKFB4 | Q16877 | 4/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13598936 | 0.81 | HTR6 (0.58) | HTR6PFKFB3PFKFB4KEAP1NPSR1 | |
| SCHEMBL13598987 | 0.77 | HTR6 (0.54) | HTR6PFKFB3PFKFB4KEAP1NPSR1 | |
| SCHEMBL3201870 | 0.75 | HTR2C (0.49) | — | |
| SCHEMBL3147230 | 0.74 | HTR6 (0.80) | HTR6KEAP1 | |
| SCHEMBL27750084 | 0.74 | HTR6 (0.58) | HTR6PFKFB3PFKFB4KEAP1NPSR1 | |
| SCHEMBL3219783 | 0.74 | HTR6 (0.54) | HTR6PFKFB3PFKFB4NPSR1L3MBTL1 | |
| SCHEMBL3209965 | 0.74 | LMNA (0.58) | — | |
| SCHEMBL3222016 | 0.73 | HTR2C (0.49) | — | |
| SCHEMBL12577072 | 0.73 | HTR6 (0.56) | HTR6PFKFB3PFKFB4KEAP1NPSR1 | |
| SCHEMBL3205229 | 0.73 | HTR6 (0.50) | HTR6KEAP1NPSR1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100029648-A1 | 11-Beta HSD1 Inhibitors | XIANG JASON SHAOYUN | 2010-02-04 | — | — | US | disclosed |
| US-7632838-B2 | 11-beta HSD1 inhibitors | WYETH (US) | 2009-12-15 | — | — | US | disclosed |
| US-20070219198-A1 | 11-Beta HSD 1 inhibitors | WYETH (US) | 2007-09-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029648-A1 | 11-Beta HSD1 Inhibitors | HSD11B1, HSD3B1, HSD11B2 | HTR6 2021/4885FPR2 3918/4885PROKR1 1585/4885 |
| US-20070219198-A1 | 11-Beta HSD 1 inhibitors | HSD11B1, HSD11B2, HSD3B1 | HTR6 1213/4885FPR2 3342/4885PROKR1 1345/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.