Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 7/20 | 0.48 |
| ▸ | HTR6 | P50406 | 13/20 | 0.44 |
| ▸ | HTR2C | P28335 | 3/20 | 0.44 |
| ▸ | HTR7 | P34969 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.42 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | FPR3 | P25089 | 1/20 | 0.42 |
| ▸ | HTR1D | P28221 | 1/20 | 0.42 |
| ▸ | HTR1B | P28222 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | GPR183 | P32249 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3208785 | 0.84 | HTR6 (0.58) | METHTR6HTR2CHTR7CYP3A4 | |
| SCHEMBL3207669 | 0.83 | MET (0.48) | METHTR6HTR2CHTR7CYP3A4 | |
| SCHEMBL3205536 | 0.82 | MET (0.47) | METHTR6HTR2CHTR7CYP3A4 | |
| SCHEMBL3198440 | 0.76 | HTR6 (0.66) | HTR6HTR7CYP3A4HTR1DHTR1B | |
| SCHEMBL3622143 | 0.73 | MET (0.50) | METHTR6HTR2CHTR7CYP3A4 | |
| SCHEMBL3190425 | 0.72 | HTR6 (0.60) | METHTR6HTR1DHTR1B | |
| Trifluoroacetic Acid SCHEMBL3618353 | 0.68 | MET (0.45) | METHTR6HTR2CHTR7CYP3A4 | |
| SCHEMBL3623245 | 0.67 | HTR6 (0.58) | METHTR6HTR2CHTR7CYP3A4 | |
| SCHEMBL1537829 | 0.67 | MET (0.65) | METHTR6HTR2CHTR7CYP3A4 | |
| SCHEMBL3326635 | 0.66 | MET (0.54) | METHTR6HTR2CHTR7CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7671079-B2 | Sulfonyltetrahydro-3H-benzo(e)indole-8-amine compounds as 5-hydroxytryptamine-6 ligands | WYETH LLC (US) | 2010-03-02 | — | — | US | claimed |
| US-7288561-B2 | Sulfonyltetrahydro-3H-benzo(E)indole-8-amine compounds as 5-hydroxytryptamine-6 ligands | WYETH (US) | 2007-10-30 | — | — | US | claimed |
| EP-1682502-A1 | SULFONYLTETRAHYDRO-3H-BENZO(E)INDOLE-8-AMINE COMPOUNDS AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | Wyeth (US) | 2006-07-26 | — | — | EP | claimed |
| WO-2005047252-A1 | SULFONYLTETRAHYDRO-3H-BENZO(E)INDOLE-8-AMINE COMPOUNDS AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | WYETH (US) | 2005-05-26 | — | — | WO | claimed |
| US-20050101596-A1 | Sulfonyltetrahydro-3H-benzo(E)indole-8-amine compounds as 5-Hydroxytryptamine-6 ligands | WYETH (US) | 2005-05-12 | — | — | US | claimed |
| US-7671079-B2 | Sulfonyltetrahydro-3H-benzo(e)indole-8-amine compounds as 5-hydroxytryptamine-6 ligands | WYETH LLC (US) | 2010-03-02 | — | — | US | disclosed |
| US-20080085925-A1 | Sulfonyltetrahydro-3H-benzo(e)indole-8-amine compounds as 5-hydroxytryptamine-6 ligands | WYETH (US) | 2008-04-10 | — | — | US | disclosed |
| US-7288561-B2 | Sulfonyltetrahydro-3H-benzo(E)indole-8-amine compounds as 5-hydroxytryptamine-6 ligands | WYETH (US) | 2007-10-30 | — | — | US | disclosed |
| EP-1682502-A1 | SULFONYLTETRAHYDRO-3H-BENZO(E)INDOLE-8-AMINE COMPOUNDS AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | Wyeth (US) | 2006-07-26 | — | — | EP | disclosed |
| WO-2005047252-A1 | SULFONYLTETRAHYDRO-3H-BENZO(E)INDOLE-8-AMINE COMPOUNDS AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | WYETH (US) | 2005-05-26 | — | — | WO | disclosed |
| US-20050101596-A1 | Sulfonyltetrahydro-3H-benzo(E)indole-8-amine compounds as 5-Hydroxytryptamine-6 ligands | WYETH (US) | 2005-05-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080085925-A1 | Sulfonyltetrahydro-3H-benzo(e)indole-8-amine compounds as 5-hydroxytryptamine-6 ligands | HTR6, HTR5A, TPH1 | MET 1870/4885HTR6 1/4885HTR2C 8/4885 |
| US-20050101596-A1 | Sulfonyltetrahydro-3H-benzo(E)indole-8-amine compounds as 5-Hydroxytryptamine-6 ligands | HTR6, HTR5A, TPH1 | MET 1870/4885HTR6 1/4885HTR2C 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.