Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.45 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.45 |
| ▸ | HCAR2 | Q8TDS4 | 5/20 | 0.45 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL29151519 | 1.00 | TSHR (0.45) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL27504923 | 1.00 | TSHR (0.45) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Maleic Acid SCHEMBL27347708 | 0.86 | SOAT1 (0.61) | TSHRTP53HCAR2SOAT1MEN1 | |
| Maleic Acid SCHEMBL30619142 | 0.84 | SOAT1 (0.64) | TSHRTP53SOAT1MEN1FAAH | |
| Maleic Acid SCHEMBL28469690 | 0.84 | SOAT1 (0.64) | TSHRTP53SOAT1MEN1FAAH | |
| Fumaric Acid SCHEMBL29516769 | 0.84 | SOAT1 (0.64) | TSHRTP53SOAT1MEN1FAAH | |
| Maleic Acid SCHEMBL30415773 | 0.84 | SOAT1 (0.64) | TSHRTP53SOAT1MEN1FAAH | |
| Butyramide SCHEMBL29130698 | 0.84 | HDAC3 (0.53) | TSHRTP53FFAR3HDAC3HDAC1 | |
| Butyramide SCHEMBL17685288 | 0.84 | HDAC3 (0.53) | TSHRTP53FFAR3HDAC3HDAC1 | |
| Butyramide SCHEMBL29130696 | 0.84 | HDAC3 (0.53) | TSHRTP53FFAR3HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023204306-A1 | RESIN COMPOSITION AND MULTILAYER LAMINATED FILM | 三井化学株式会社 | 2023-10-26 | — | — | WO | disclosed |
| US-20100035073-A1 | AQUEOUS EMULSION OF OLEFIN COPOLYMER | SUMIKA CHEMTEX COMPANY, LIMITED (JP) | 2010-02-11 | — | — | US | disclosed |
| EP-2096138-A1 | AQUEOUS EMULSION OF OLEFIN COPOLYMER | Sumika Chemtex Company, Limited (JP) | 2009-09-02 | — | — | EP | disclosed |