Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.50 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.50 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 11/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1920762 | 0.89 | CHRM2 (0.50) | CHRM2CHRM4CHRM1CHRM3POLB | |
| SCHEMBL13696680 | 0.85 | CHRM2 (0.59) | CHRM2CHRM4CHRM1CHRM3POLB | |
| SCHEMBL30022454 | 0.85 | CHRM2 (0.59) | CHRM2CHRM4CHRM1CHRM3POLB | |
| SCHEMBL3197264 | 0.82 | CDK1 (0.47) | CHRM2CHRM4CHRM1CHRM3NR1H2 | |
| SCHEMBL1920867 | 0.82 | GABRG2 (0.42) | CHRM2CHRM4CHRM1CHRM3NR1H2 | |
| SCHEMBL17897786 | 0.81 | CHRM2 (0.50) | CHRM2CHRM4CHRM1CHRM3POLB | |
| SCHEMBL12961033 | 0.80 | CHRM2 (0.50) | CHRM2CHRM4CHRM1CHRM3POLB | |
| SCHEMBL15280123 | 0.80 | CHRM2 (0.50) | CHRM2CHRM4CHRM1CHRM3POLB | |
| SCHEMBL27938900 | 0.80 | CHRM2 (0.43) | CHRM2CHRM4CHRM1CHRM3L3MBTL1 | |
| SCHEMBL23875375 | 0.79 | CHRM2 (0.45) | CHRM2CHRM4CHRM1CHRM3POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2326327-B1 | ANALOGS OF INDOLE-3-CARBINOL AND THEIR USE AS AGENTS AGAINST INFECTION | STANFORD RES INST INT (US) | 2016-03-23 | — | — | EP | disclosed |
| US-8399502-B2 | Analogs of indole-3-carbinol and their use as agents against infection | SRI INTERNATIONAL (US) | 2013-03-19 | — | — | US | disclosed |
| US-20120283240-A1 | Analogs of Indole-3-Carbinol and Their Use as Agents Against Infection | SRI INTERNATIONAL | 2012-11-08 | — | — | US | disclosed |
| US-8278341-B2 | Analogs of indole-3-carbinol and their use as agents against infection | SRI INTERNATIONAL (US) | 2012-10-02 | — | — | US | disclosed |
| US-20100069355-A1 | Analogs of Indole-3-Carbinol and Their Use as Agents Against Infection | UNITED STATES GOVERNMENT; DEFENSE THREAT REDUCTION AGENCY | 2010-03-18 | — | — | US | disclosed |
| US-7666897-B2 | Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents | SRI INTERNATIONAL (US) | 2010-02-23 | — | — | US | disclosed |
| US-20090023796-A1 | Analogs of Indole-3-Carbinol Metabolites as Chemotherapeutic and Chemopreventive Agents | SRI INTERNATIONAL (US) | 2009-01-22 | — | — | US | disclosed |
| EP-1530572-B1 | ANALOGS OF INDOLE-3-CARBINOL METABOLITES AS CHEMOTHERAPEUTIC AND CHEMOPREVENTIVE AGENTS | STANFORD RES INST INT (US) | 2008-10-15 | — | — | EP | disclosed |
| US-7429610-B2 | Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents | SRI INTERNATIONAL (US) | 2008-09-30 | — | — | US | disclosed |
| US-7078427-B2 | Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents | SRI INTERNATIONAL (US) | 2006-07-18 | — | — | US | disclosed |
| US-20060128785-A1 | Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents | SRI INTERNATIONAL (US) | 2006-06-15 | — | — | US | disclosed |
| EP-1623985-A2 | Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventative agents | Sri International (US) | 2006-02-08 | — | — | EP | disclosed |
| US-6800655-B2 | Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents | SRI INTERNATIONAL | 2004-10-05 | — | — | US | disclosed |
| US-20040157906-A1 | Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents | JONG LING (US) | 2004-08-12 | — | — | US | disclosed |
| US-20040043965-A1 | Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents | SRI INTERNATIONAL | 2004-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120283240-A1 | Analogs of Indole-3-Carbinol and Their Use as Agents Against Infection | IDO1, IDO2, TDO2 | CHRM2 1115/4885CHRM4 2441/4885CHRM1 1042/4885 |
| US-20060128785-A1 | Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents | IDO1, CCND3, FOXM1 | CHRM2 69/4885CHRM4 812/4885CHRM1 68/4885 |
| US-20100069355-A1 | Analogs of Indole-3-Carbinol and Their Use as Agents Against Infection | IDO1, IDO2, TDO2 | CHRM2 1115/4885CHRM4 2441/4885CHRM1 1042/4885 |
| US-20090023796-A1 | Analogs of Indole-3-Carbinol Metabolites as Chemotherapeutic and Chemopreventive Agents | IDO1, CCND3, CCNA1 | CHRM2 41/4885CHRM4 397/4885CHRM1 73/4885 |
| US-20040043965-A1 | Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents | IDO1, IDO2, TPH1 | CHRM2 419/4885CHRM4 1647/4885CHRM1 264/4885 |
| US-20040157906-A1 | Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents | IDO1, IDO2, TPH1 | CHRM2 419/4885CHRM4 1647/4885CHRM1 264/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.