Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 10/20 | 0.55 |
| ▸ | CA12 | O43570 | 3/20 | 0.55 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.55 |
| ▸ | MMP1 | P03956 | 7/20 | 0.47 |
| ▸ | MMP9 | P14780 | 7/20 | 0.47 |
| ▸ | MMP13 | P45452 | 7/20 | 0.47 |
| ▸ | CA2 | P00918 | 3/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | MMP8 | P22894 | 1/20 | 0.47 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.45 |
| ▸ | MMP3 | P08254 | 6/20 | 0.45 |
| ▸ | MMP7 | P09237 | 6/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MMP14 | P50281 | 1/20 | 0.42 |
| ▸ | F2 | P00734 | 2/20 | 0.42 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.42 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.42 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.42 |
| ▸ | CA9 | Q16790 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL152957 | 0.82 | MMP2 (0.53) | MMP2CA12CA14MMP1MMP9 | |
| SCHEMBL10767453 | 0.80 | MMP2 (0.49) | MMP2CA12CA14MMP1MMP9 | |
| SCHEMBL5335059 | 0.80 | GAA (0.52) | MMP2CA12CA14MMP1MMP9 | |
| SCHEMBL17674087 | 0.79 | MMP2 (0.44) | MMP2CA12CA14MMP1MMP9 | |
| SCHEMBL14850017 | 0.78 | MMP2 (0.50) | MMP2CA12CA14MMP1MMP9 | |
| SCHEMBL21921004 | 0.78 | CA12 (0.55) | MMP2CA12CA14MMP1MMP9 | |
| SCHEMBL7758469 | 0.78 | TSHR (0.52) | MMP2CA12CA14MMP1MMP9 | |
| SCHEMBL9646612 | 0.78 | MMP13 (0.34) | MMP2CA12CA14MMP1MMP13 | |
| SCHEMBL26460446 | 0.78 | MMP2 (0.50) | MMP2CA12CA14MMP1MMP9 | |
| SCHEMBL8013573 | 0.78 | MMP2 (0.55) | MMP2CA12CA14MMP1MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014015675-A1 | NOVEL HETEROARYL AND HETEROCYCLE COMPOUNDS, COMPOSITIONS AND METHODS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2014-01-30 | — | — | WO | disclosed |
| WO-2014015830-A1 | NOVEL HETEROARYL AND HETEROCYCLE COMPOUNDS, COMPOSITION AND METHODS THEREOF | HUTCHISON MEDIPHARMA LIMITED (CN) | 2014-01-30 | — | — | WO | disclosed |
| WO-2012040242-A1 | SUBSTITUTED PROLINE INHIBITORS OF HEPATITIS C VIRUS REPLICATION | INTERMUNE, INC. (US) | 2012-03-29 | — | — | WO | disclosed |
| WO-2012026106-A1 | OPTICALLY ACTIVE NOVEL ANTI-INFLAMMATORY COMPOUND AND METHOD FOR PRODUCING SAME | 国立大学法人 東京大学 (JP) | 2012-03-01 | — | — | WO | disclosed |