Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.42 |
| ▸ | TRPV3 | Q8NET8 | 3/20 | 0.41 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | CES2 | O00748 | 2/20 | 0.38 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.37 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | NFKBIA | P25963 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MPL | P40238 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10021613 | 0.84 | HSD11B1 (0.41) | KCNH2SCN9AHSD11B1TSHRGLA | |
| SCHEMBL2615355 | 0.84 | MPL (0.50) | CYP1A2ALOX5APFEN1HSD11B1MPL | |
| SCHEMBL2615844 | 0.83 | HSD11B1 (0.43) | CYP1A2HSD11B1 | |
| SCHEMBL15081823 | 0.81 | KCNH2 (0.41) | KCNH2CYP1A2TRPV3ALOX5APFEN1 | |
| SCHEMBL16254008 | 0.80 | KCNH2 (0.50) | KCNH2CYP1A2TRPV3ALOX5APFEN1 | |
| SCHEMBL25400896 | 0.80 | TP53 (0.48) | CYP1A2ALOX5APFEN1SCN9ATP53 | |
| SCHEMBL15354821 | 0.80 | HDAC1 (0.34) | KCNH2CYP1A2TRPV3CYP2C9HSD11B1 | |
| SCHEMBL31399815 | 0.80 | TP53 (0.48) | CYP1A2ALOX5APFEN1SCN9ATP53 | |
| SCHEMBL13265493 | 0.80 | CYP1A2 (0.39) | KCNH2CYP1A2ALOX5APFEN1HSD11B1 | |
| SCHEMBL4049824 | 0.80 | CRHR1 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8815858-B2 | Heterocyclic flaviviridae virus inhibitors | GILEAD SCIENCES, INC. (US) | 2014-08-26 | — | — | US | disclosed |
| US-8569488-B2 | Crystalline pyridazine compound | GILEAD SCIENCES, INC. (US) | 2013-10-29 | — | — | US | disclosed |
| US-8569488-B2 | Crystalline pyridazine compound | GILEAD SCIENCES, INC. (US) | 2013-10-29 | — | — | US | disclosed |
| US-8569487-B2 | Pyridazine compound and use thereof | GILEAD SCIENCES, INC. (US) | 2013-10-29 | — | — | US | disclosed |
| US-8569487-B2 | Pyridazine compound and use thereof | GILEAD SCIENCES, INC. (US) | 2013-10-29 | — | — | US | disclosed |
| US-20130171102-A1 | HETEROCYCLIC FLAVIVIRIDAE VIRUS INHIBITORS | GILEAD SCIENCES, INC. (US) | 2013-07-04 | — | — | US | disclosed |
| US-20120108601-A1 | CRYSTALLINE PYRIDAZINE COMPOUND | GILEAD SCIENCES, INC. (US) | 2012-05-03 | — | — | US | disclosed |
| US-20120108601-A1 | CRYSTALLINE PYRIDAZINE COMPOUND | GILEAD SCIENCES, INC. (US) | 2012-05-03 | — | — | US | disclosed |
| US-8106054-B2 | Crystalline pyridazine compound | GILEAD SCIENCES, INC. (US) | 2012-01-31 | — | — | US | disclosed |
| US-8106054-B2 | Crystalline pyridazine compound | GILEAD SCIENCES, INC. (US) | 2012-01-31 | — | — | US | disclosed |
| WO-2010006096-A1 | PROCESSES FOR THE PREPARATION OF ANTI-VIRAL COMPOUNDS AND COMPOSITIONS CONTAINING THEM | SMITHKLINE BEECHAM CORPORATION (US) | 2010-01-14 | — | — | WO | disclosed |
| EP-2038275-B1 | NOVEL PYRIDAZINE COMPOUND AND USE THEREOF | GILEAD SCIENCES INC (US) | 2010-01-06 | — | — | EP | disclosed |
| WO-2009111501-A1 | DERIVATIVES OF IMIDAZO [4, 5-D] PYRIDAZINE AND THEIR USE AS ANTI-VIRAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-09-11 | — | — | WO | disclosed |
| US-20090226398-A1 | ANTI-VIRAL COMPOUNDS, COMPOSITIONS, AND METHODS OF USE | GENELABS TECHNOLOGIES, INC. | 2009-09-10 | — | — | US | disclosed |
| US-20090036460-A1 | Crystalline pyridazine compound | GILEAD SCIENCES, INC. (US) | 2009-02-05 | — | — | US | disclosed |
| US-20090036460-A1 | Crystalline pyridazine compound | GILEAD SCIENCES, INC. (US) | 2009-02-05 | — | — | US | disclosed |
| WO-2009009001-A1 | CRYSTALLINE PYRIDAZINE COMPOUND | GILEAD SCIENCES, INC. (US) | 2009-01-15 | — | — | WO | disclosed |
| US-20080199427-A1 | Novel pyridazine compound and use thereof | K.U. LEUVEN RESEARCH & DEVELOPMENT (BE) | 2008-08-21 | — | — | US | disclosed |
| US-20080199427-A1 | Novel pyridazine compound and use thereof | K.U. LEUVEN RESEARCH & DEVELOPMENT (BE) | 2008-08-21 | — | — | US | disclosed |
| WO-2008005519-A2 | NOVEL PYRIDAZINE COMPOUND AND USE THEREOF | GILEAD SCIENCES, INC. (US) | 2008-01-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130171102-A1 | HETEROCYCLIC FLAVIVIRIDAE VIRUS INHIBITORS | EIF2AK2, MAVS, ZC3HAV1 | KCNH2 1890/4885CYP1A2 61/4885TRPV3 3926/4885 |
| US-20120108601-A1 | CRYSTALLINE PYRIDAZINE COMPOUND | CYP2F1, HAVCR2, NOD1 | KCNH2 1752/4885CYP1A2 39/4885TRPV3 3652/4885 |
| US-20090226398-A1 | ANTI-VIRAL COMPOUNDS, COMPOSITIONS, AND METHODS OF USE | MAVS, SARS1, HAVCR2 | KCNH2 2124/4885CYP1A2 1975/4885TRPV3 1071/4885 |
| US-20080199427-A1 | Novel pyridazine compound and use thereof | CYP2F1, HAVCR2, CYP4F2 | KCNH2 978/4885CYP1A2 18/4885TRPV3 3157/4885 |
| US-20090036460-A1 | Crystalline pyridazine compound | CYP2F1, HAVCR2, NOD1 | KCNH2 1752/4885CYP1A2 39/4885TRPV3 3652/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.