Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 3/20 | 0.71 |
| ▸ | HTR6 | P50406 | 3/20 | 0.71 |
| ▸ | HTR1A | P08908 | 1/20 | 0.52 |
| ▸ | DRD2 | P14416 | 1/20 | 0.52 |
| ▸ | HTR7 | P34969 | 1/20 | 0.52 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.49 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.42 |
| ▸ | CKS1B | P61024 | 2/20 | 0.42 |
| ▸ | SKP1 | P63208 | 2/20 | 0.42 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HPGDS | O60760 | 1/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2197307 | 0.91 | HTR2A (0.63) | HTR2AHTR6HTR1ADRD2HTR7 | |
| SCHEMBL2197469 | 0.89 | HTR6 (0.56) | HTR2AHTR6HTR1ADRD2HTR7 | |
| SCHEMBL2195197 | 0.87 | HTR2A (0.59) | HTR2AHTR6HTR1ADRD2HTR7 | |
| SCHEMBL4386582 | 0.86 | HTR6 (0.67) | HTR2AHTR6HTR1ADRD2HTR7 | |
| SCHEMBL3649774 | 0.84 | HTR2A (0.59) | HTR2AHTR6HTR1ADRD2HTR7 | |
| SCHEMBL3649776 | 0.84 | HTR2A (0.59) | HTR2AHTR6HTR1ADRD2HTR7 | |
| SCHEMBL3132360 | 0.83 | HTR6 (1.00) | HTR2AHTR6HTR1ADRD2HTR7 | |
| SCHEMBL4701194 | 0.83 | HTR2A (0.51) | HTR2AHTR6HTR1ADRD2HTR7 | |
| SCHEMBL4701379 | 0.81 | TGM2 (0.47) | HTR2AHTR6HTR1ADRD2HTR7 | |
| SCHEMBL3740556 | 0.81 | HTR2A (0.51) | HTR2AHTR6HTR1ADRD2HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2120950-B1 | USE OF QUINOLINE DERIVATIVES IN THE TREATMENT OF PAIN | GLAXO GROUP LTD (GB) | 2012-07-04 | — | — | EP | disclosed |
| US-20100041672-A1 | USE OF QUINOLINE DERIVATIVES IN THE TREATMENT OF PAIN AND IRRITABLE BOWEL SYNDROME | GLAXO GROUP LIMITED (GB) | 2010-02-18 | — | — | US | disclosed |
| US-20100041672-A1 | USE OF QUINOLINE DERIVATIVES IN THE TREATMENT OF PAIN AND IRRITABLE BOWEL SYNDROME | GLAXO GROUP LIMITED (GB) | 2010-02-18 | — | — | US | disclosed |
| US-20100041672-A1 | USE OF QUINOLINE DERIVATIVES IN THE TREATMENT OF PAIN AND IRRITABLE BOWEL SYNDROME | GLAXO GROUP LIMITED (GB) | 2010-02-18 | — | — | US | disclosed |
| EP-2120950-A1 | USE OF QUINOLINE DERIVATIVES IN THE TREATMENT OF PAIN AND IRRITABLE BOWEL SYNDROME | Glaxo Group Limited (GB) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008113818-A1 | USE OF QUINOLINE DERIVATIVES IN THE TREATMENT OF PAIN AND IRRITABLE BOWEL SYNDROME | GLAXO GROUP LIMITED (GB) | 2008-09-25 | — | — | WO | disclosed |
| WO-2008113818-A1 | USE OF QUINOLINE DERIVATIVES IN THE TREATMENT OF PAIN AND IRRITABLE BOWEL SYNDROME | GLAXO GROUP LIMITED (GB) | 2008-09-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100041672-A1 | USE OF QUINOLINE DERIVATIVES IN THE TREATMENT OF PAIN AND IRRITABLE BOWEL SYNDROME | HTR6, TPH1, HRH2 | HTR2A 16/4885HTR6 1/4885HTR1A 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.