Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 4/20 | 0.67 |
| ▸ | HTR2A | P28223 | 3/20 | 0.67 |
| ▸ | HTR1A | P08908 | 2/20 | 0.48 |
| ▸ | DRD2 | P14416 | 2/20 | 0.48 |
| ▸ | HTR7 | P34969 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3204503 | 0.86 | HTR2A (0.71) | HTR6HTR2AHTR1ADRD2HTR7 | |
| SCHEMBL5758760 | 0.84 | HTR2A (0.48) | HTR6HTR2AHTR1ADRD2HTR7 | |
| SCHEMBL5757481 | 0.83 | LMNA (0.47) | HTR6HTR2AHTR1ADRD2HTR7 | |
| SCHEMBL5758622 | 0.81 | HTT (0.44) | HTR6HTR2AHTR1ADRD2HTR7 | |
| SCHEMBL3132360 | 0.81 | HTR6 (1.00) | HTR6HTR2AHTR1ADRD2HTR7 | |
| SCHEMBL5757786 | 0.80 | LMNA (0.45) | HTR6HTR2AHTR1ADRD2HTR7 | |
| SCHEMBL3917828 | 0.80 | MAPT (0.43) | HTR6HTR2AHTR1AMAPTLMNA | |
| SCHEMBL5698823 | 0.79 | SMN1; SMN2 (0.41) | MAPTLMNAALDH1A1HTTHPGD | |
| SCHEMBL19327101 | 0.79 | HTR2A (0.65) | HTR6HTR2AHTR1ADRD2HTR7 | |
| SCHEMBL19327037 | 0.77 | HTR6 (0.74) | HTR6HTR2AHTR1ADRD2HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2120950-A1 | USE OF QUINOLINE DERIVATIVES IN THE TREATMENT OF PAIN AND IRRITABLE BOWEL SYNDROME | Glaxo Group Limited (GB) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008113818-A1 | USE OF QUINOLINE DERIVATIVES IN THE TREATMENT OF PAIN AND IRRITABLE BOWEL SYNDROME | GLAXO GROUP LIMITED (GB) | 2008-09-25 | — | — | WO | disclosed |