Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | PAK4 | O96013 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | FYN | P06241 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29213168 | 0.75 | LMNA (0.34) | LMNACYP1A2CYP3A4MAPK1TP53 | |
| SCHEMBL15661815 | 0.75 | HDAC4 (0.38) | LMNACYP1A2CYP3A4MAPK1TP53 | |
| SCHEMBL6673270 | 0.75 | GAA (0.35) | LMNACYP1A2CYP3A4MAPK1TP53 | |
| SCHEMBL7191962 | 0.73 | LMNA (0.33) | LMNACYP1A2CYP3A4MAPK1TP53 | |
| Hydrochloric Acid SCHEMBL29281384 | 0.73 | LMNA (0.34) | LMNACYP1A2CYP3A4MAPK1TP53 | |
| Hydrochloric Acid SCHEMBL6129919 | 0.73 | LMNA (0.34) | LMNACYP1A2CYP3A4MAPK1TP53 | |
| SCHEMBL1387828 | 0.73 | CFTR (0.38) | LMNACYP1A2CYP3A4MAPK1TP53 | |
| SCHEMBL29115214 | 0.72 | ALDH1A1 (0.33) | LMNACYP1A2CYP3A4MAPK1TP53 | |
| Fluoride Ion SCHEMBL1130163 | 0.72 | LMNA (0.32) | LMNACYP1A2CYP3A4MAPK1TP53 | |
| SCHEMBL6912880 | 0.71 | LMNA (0.35) | LMNACYP1A2CYP3A4MAPK1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7683097-B2 | Topoisomerase inhibitors | Propharmacon Inc. (US) | 2010-03-23 | — | — | US | disclosed |
| WO-2006022955-A2 | TOPOISOMERASE INHIBITORS | PROPHARMACON, INC. (US) | 2006-03-02 | — | — | WO | disclosed |