Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.52 |
| ▸ | TSHR | P16473 | 3/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CASR | P41180 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | PTGES | O14684 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11870677 | 0.86 | TSHR (0.38) | CYP3A4TSHRMAPK1TDP1HSD11B1 | |
| SCHEMBL11869739 | 0.85 | TSHR (0.65) | CYP3A4TSHRMAPK1TDP1HSD11B1 | |
| SCHEMBL11865649 | 0.83 | KCNN4 (0.41) | CYP3A4TSHRMAPK1TDP1CYP19A1 | |
| SCHEMBL4465602 | 0.82 | TSHR (0.73) | CYP3A4TSHRMAPK1TDP1TP53 | |
| SCHEMBL4470018 | 0.80 | KCNN4 (0.41) | TSHRNFE2L2 | |
| SCHEMBL11866631 | 0.77 | KIF18A (0.46) | CYP3A4TSHRMAPK1MEN1KMT2A | |
| SCHEMBL11864594 | 0.76 | NFE2L2 (0.39) | CYP3A4TSHRMAPK1CYP19A1MEN1 | |
| SCHEMBL6203055 | 0.76 | TSHR (0.57) | CYP3A4TSHRMAPK1TDP1CYP19A1 | |
| SCHEMBL11862480 | 0.75 | KIF11 (0.41) | CYP3A4CYP19A1MEN1KMT2ACYP3A5 | |
| SCHEMBL11862899 | 0.73 | TSHR (0.48) | CYP3A4TSHRMAPK1TDP1HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1896445-B1 | ( 6-FLU0R0-BENZ0[l, 3] DIOXOLYL) -MORPHOLIN-4-YL-METHANONES AND THEIR USE AS CBl LIGANDS | HOFFMANN LA ROCHE (CH) | 2010-11-10 | — | — | EP | disclosed |
| US-20100056513-A1 | STEREOSPECIFICALLY SUBSTITUTED BENZO[1,3]DIOXOLYL DERIVATIVES | FREI BEAT | 2010-03-04 | — | — | US | disclosed |
| EP-1896445-A1 | ( 6-FLU0R0-BENZ0[l, 3] DIOXOLYL) -MORPHOLIN-4-YL-METHANONES AND THEIR USE AS CBl LIGANDS | F. Hoffmann-Roche AG (CH) | 2008-03-12 | — | — | EP | disclosed |
| WO-2006136502-A1 | ( 6-FLU0R0-BENZ0[l, 3] DIOXOLYL) -MORPHOLIN-4-YL-METHANONES AND THEIR USE AS CBl LIGANDS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-12-28 | — | — | WO | disclosed |
| US-20060293318-A1 | Stereospecifically substituted benzo[1,3]dioxolyl derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2006-12-28 | — | — | US | disclosed |
| US-3985766-A | ANTIMYCOTICS | BAYER AKTIENGESELLSCHAFT (DT) | 1976-10-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060293318-A1 | Stereospecifically substituted benzo[1,3]dioxolyl derivatives | CNR1, CNR2, NPY1R | CYP3A4 835/4885TSHR 530/4885MAPK1 1038/4885 |
| US-20100056513-A1 | STEREOSPECIFICALLY SUBSTITUTED BENZO[1,3]DIOXOLYL DERIVATIVES | CNR1, CNR2, NPY1R | CYP3A4 835/4885TSHR 530/4885MAPK1 1038/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.