Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNN4 | O15554 | 5/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.36 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
| ▸ | KIF11 | P52732 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.32 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.32 |
| ▸ | MLNR | O43193 | 1/20 | 0.32 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.32 |
| ▸ | CCKBR | P32239 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11865649 | 0.89 | KCNN4 (0.41) | KCNN4ACHEKCNE1KCNQ1NFE2L2 | |
| SCHEMBL11868726 | 0.87 | ACHE (0.50) | KCNN4ACHEKCNE1KCNQ1ALDH1A1 | |
| SCHEMBL11861229 | 0.85 | KCNN4 (0.48) | KCNN4ACHEKCNE1KCNQ1ALDH1A1 | |
| SCHEMBL5720357 | 0.83 | KCNN4 (0.41) | KCNN4ACHEKCNE1KCNQ1NFE2L2 | |
| SCHEMBL30211828 | 0.83 | KCNN4 (0.41) | KCNN4ACHEKCNE1KCNQ1NFE2L2 | |
| SCHEMBL11862432 | 0.82 | KCNN4 (0.51) | KCNN4KCNE1KCNQ1NFE2L2KIF11 | |
| SCHEMBL5668721 | 0.81 | KCNN4 (0.39) | KCNN4ACHEKCNE1KCNQ1NFE2L2 | |
| SCHEMBL11870677 | 0.80 | TSHR (0.38) | KCNN4NFE2L2ALDH1A1TSHR | |
| SCHEMBL3206408 | 0.80 | CYP3A4 (0.52) | NFE2L2TSHR | |
| SCHEMBL11864594 | 0.80 | NFE2L2 (0.39) | KCNN4KCNE1KCNQ1NFE2L2KIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7576088-B2 | Benzodioxole derivatives | HOFFMAN-LA ROCHE INC. (US) | 2009-08-18 | — | — | US | disclosed |
| EP-1532132-B1 | NOVEL BENZODIOXOLES | HOFFMANN LA ROCHE (CH) | 2008-03-19 | — | — | EP | disclosed |
| US-20050143373-A1 | Benzodioxole derivatives | ALANINE ALEXANDER (FR) | 2005-06-30 | — | — | US | disclosed |
| US-6900227-B2 | Benzodioxole derivatives | HOFFMANN-LA ROCHE INC. (US) | 2005-05-31 | — | — | US | disclosed |
| EP-1532132-A1 | NOVEL BENZODIOXOLES | F.HOFFMANN-LA ROCHE AG (CH) | 2005-05-25 | — | — | EP | disclosed |
| US-20040142922-A1 | Benzodioxole derivatives | HOFFMANN-LA ROCHE INC. | 2004-07-22 | — | — | US | disclosed |
| WO-2004013120-A1 | NOVEL BENZODIOXOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2004-02-12 | — | — | WO | disclosed |
| US-6632949-B2 | Difluoro-diamine methylene derivatives | MITSUI CHEMICALS, INC. (JP) | 2003-10-14 | — | — | US | disclosed |
| US-20030004348-A1 | Halogenating agents | SONODA HIROSHI (JP) | 2003-01-02 | — | — | US | disclosed |
| US-3985766-A | ANTIMYCOTICS | BAYER AKTIENGESELLSCHAFT (DT) | 1976-10-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050143373-A1 | Benzodioxole derivatives | CNR2, CNR1, GPR119 | KCNN4 1843/4885ACHE 3827/4885KCNE1 1866/4885 |
| US-20030004348-A1 | Halogenating agents | AFF1, NAF1, AFF2 | KCNN4 2361/4885ACHE 4429/4885KCNE1 1406/4885 |
| US-20040142922-A1 | Benzodioxole derivatives | CNR1, CNR2, GPR119 | KCNN4 1690/4885ACHE 4242/4885KCNE1 1390/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.