Sugi Predict

Sugi Predict / Compounds / SCHEMBL320812

SCHEMBL320812

SCHEMBL320812

CCOC(=O)c1c(Cl)ccnc1Cl

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CA12 O43570 1/20 0.47
▸ CA1 P00915 1/20 0.47
▸ CA2 P00918 1/20 0.47
▸ CA7 P43166 1/20 0.47
▸ CA9 Q16790 1/20 0.47
▸ CA14 Q9ULX7 1/20 0.47
▸ PDE4B Q07343 1/20 0.45
▸ MAPT P10636 6/20 0.44
▸ LMNA P02545 5/20 0.44
▸ ALDH1A1 P00352 4/20 0.44
▸ GAA P10253 2/20 0.44
▸ NPSR1 Q6W5P4 4/20 0.44
▸ HTT P42858 2/20 0.44
▸ NPC1 O15118 3/20 0.43
▸ RAB9A P51151 2/20 0.43
▸ TP53 P04637 2/20 0.43
▸ CASP1 P29466 1/20 0.43
▸ SMN1; SMN2 Q16637 2/20 0.42
▸ NUDT1 P36639 1/20 0.42
▸ NR1H2 P55055 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30666434 1.00 CA12 (0.47) CA12CA1CA2CA7CA9
SCHEMBL14911517 0.88 LMNA (0.43) CA12CA1CA2CA7CA9
SCHEMBL2527607 0.87 CA12 (0.47) CA12CA1CA2CA7CA9
SCHEMBL8840548 0.87 PDE4B (0.48) CA12CA1CA2CA7CA9
SCHEMBL31151022 0.87 PDE4B (0.48) CA12CA1CA2CA7CA9
SCHEMBL17793761 0.85 CA12 (0.59) CA12CA1CA2CA7CA9
SCHEMBL30634908 0.85 NUDT1 (0.51) CA12CA1CA2CA7CA9
SCHEMBL3515876 0.85 NUDT1 (0.51) CA12CA1CA2CA7CA9
SCHEMBL14758321 0.84 ESR1 (0.49) MAPTLMNAALDH1A1GAARAB9A
SCHEMBL843997 0.84 ADORA3 (0.47) CA12CA1CA2CA7CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 91 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109651241-A A kind of synthetic method of the bromo- 6- chlorine cigarette aldehyde of 4- 上海毕得医药技术有限公司 2019-04-19 — — CN claimed
US-12595245-B2 Inhibitors of MET kinase CELYN THERAPEUTICS, INC. (US) 2026-04-07 — — US disclosed
EP-4448510-A1 INHIBITORS OF MET KINASE Kinnate Biopharma Inc. (US) 2024-10-23 — — EP disclosed
US-20240150293-A1 SPIROCYCLOHEXANE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES AS ANTI-APOPTOTIC INHIBITORS VERNALIS (R&D) LTD (GB) 2024-05-09 — — US disclosed
US-20240067626-A1 INHIBITORS OF MET KINASE CELYN THERAPEUTICS, INC. 2024-02-29 — — US disclosed
EP-4277892-A1 SPIROCYCLOHEXANE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES AS ANTI-APOPTOTIC INHIBITORS Les Laboratoires Servier (FR) 2023-11-22 — — EP disclosed
CN-116940552-A Spirocyclic hexane derivatives, pharmaceutical compositions containing them and their use as anti-apoptotic inhibitors 法国施维雅药厂 2023-10-24 — — CN disclosed
US-11753395-B2 Inhibitors of MET kinase KINNATE BIOPHARMA INC. (US) 2023-09-12 — — US disclosed
US-20230219929-A1 INHIBITORS OF MET KINASE CELYN THERAPEUTICS, INC. 2023-07-13 — — US disclosed
WO-2023114809-A1 INHIBITORS OF MET KINASE KINNATE BIOPHARMA INC. (US) 2023-06-22 — — WO disclosed
WO-2008033999-A2 KINASE INHIBITORS USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES DECIPHERA PHARMACEUTICALS, LLC (US) 2008-03-20 — — WO disclosed
CN-101137643-A Novel pyridine compounds ASTRAZENECA AB (SE) 2008-03-05 — — CN disclosed
WO-2008024725-A1 AZA-BENZOFURANYL COMPOUNDS AND METHODS OF USE GENENTECH, INC. (US) 2008-02-28 — — WO disclosed
WO-2008024725-A1 AZA-BENZOFURANYL COMPOUNDS AND METHODS OF USE GENENTECH, INC. (US) 2008-02-28 — — WO disclosed
CN-101001851-A Hydroxyamide compounds having activity as inhibitors of histone deacetylase (HDAC) ASTELLAS PHARMA INC (JP) 2007-07-18 — — CN disclosed
CN-1874769-A Heterocyclic inhibitors of MEK and methods of use thereof ARRAY BIOPHARMA INC (US) 2006-12-06 — — CN disclosed
CN-1186322-C Proline derivatives and use thereof as drugs MITSUBISHI PHARMACEUTICAL CO L (JP) 2005-01-26 — — CN disclosed
CN-1131212-C Phenyl-and pyridinyl derivatives HOFFMANN LA ROCHE (CH) 2003-12-17 — — CN disclosed
CN-1441779-A Proline derivatives and use thereof as drugs MITSUBISHI PHARMACEUTICAL CO L (JP) 2003-09-10 — — CN disclosed
CN-1341101-A Phenyl-and pyridinyl derivatives HOFFMANN LA ROCHE (CH) 2002-03-20 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240150293-A1 SPIROCYCLOHEXANE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES AS ANTI-APOPTOTIC INHIBITORS BCL2, BAX, BCL2A1 CA12 3358/4885CA1 2391/4885CA2 1311/4885
US-12595245-B2 Inhibitors of MET kinase MET, ABL1, ERBB2 CA12 4228/4885CA1 3222/4885CA2 1171/4885
US-20230219929-A1 INHIBITORS OF MET KINASE MET, RET, MERTK CA12 3989/4885CA1 4509/4885CA2 2964/4885
US-11753395-B2 Inhibitors of MET kinase MET, RET, MERTK CA12 3989/4885CA1 4509/4885CA2 2964/4885
US-20240067626-A1 INHIBITORS OF MET KINASE MET, RET, MERTK CA12 3989/4885CA1 4509/4885CA2 2964/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.