Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.70 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.54 |
| ▸ | TGM2 | P21980 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.49 |
| ▸ | KIF11 | P52732 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | DHODH | Q02127 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3208946 | 1.00 | ALDH1A1 (0.70) | ALDH1A1EPHX2TGM2MAPTTRPV1 | |
| SCHEMBL11345591 | 0.87 | MAPT (0.53) | ALDH1A1MAPTNPC1RAB9AMEN1 | |
| SCHEMBL13377982 | 0.82 | MAPT (0.67) | ALDH1A1MAPTNPC1RAB9AMEN1 | |
| SCHEMBL2879006 | 0.82 | MAPT (0.67) | ALDH1A1MAPTNPC1RAB9AMEN1 | |
| SCHEMBL2879004 | 0.82 | MAPT (0.67) | ALDH1A1MAPTNPC1RAB9AMEN1 | |
| SCHEMBL12264384 | 0.82 | SMN1; SMN2 (0.62) | ALDH1A1TGM2MAPTNPC1RAB9A | |
| SCHEMBL2547131 | 0.82 | SMN1; SMN2 (0.62) | ALDH1A1TGM2MAPTNPC1RAB9A | |
| SCHEMBL3737334 | 0.82 | MAPT (0.60) | ALDH1A1MAPTNPC1RAB9AMEN1 | |
| SCHEMBL3737335 | 0.82 | MAPT (0.60) | ALDH1A1MAPTNPC1RAB9AMEN1 | |
| SCHEMBL13628941 | 0.82 | MAPT (0.60) | ALDH1A1MAPTNPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1594843-B1 | METHOD FOR PRODUCING AN OPTICALLY ACTIVE beta-amino acid derivative | TAKASAGO PERFUMERY CO LTD (JP) | 2013-05-22 | — | — | EP | disclosed |
| US-8188307-B2 | Method for producing an optically active tetrahydroquinoline | TAKASAGO INTERNATIONAL CORPORATION (JP) | 2012-05-29 | — | — | US | disclosed |
| US-20100036149-A1 | METHOD FOR PRODUCING AN OPTICALLY ACTIVE TETRAHYDROQUINOLINE | TAKASAGO INTERNATIONAL COPORATION (JP) | 2010-02-11 | — | — | US | disclosed |
| US-7601842-B2 | Method for producing an optically active tetrahydroquinoline | TAKASAGO INTERNATIONAL CORPORATION (JP) | 2009-10-13 | — | — | US | disclosed |
| US-20060122225-A1 | Method for producing an optically active tetrahydroquinoline | TAKASAGO INTERNATIONAL CORPORATION (JP) | 2006-06-08 | — | — | US | disclosed |
| EP-1594843-A2 | METHOD FOR PRODUCING AN OPTICALLY ACTIVE TETRAHYDROQUINOLINE | Takasago International Corporation (JP) | 2005-11-16 | — | — | EP | disclosed |
| WO-2004074255-A2 | METHOD FOR PRODUCING AN OPTICALLY ACTIVE TETRAHYDROQUINOLINE | TAKASAGO INTERNATIONAL CORPORATION (JP) | 2004-09-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100036149-A1 | METHOD FOR PRODUCING AN OPTICALLY ACTIVE TETRAHYDROQUINOLINE | AADAT, KMO, ALDH7A1 | ALDH1A1 390/4885EPHX2 749/4885TGM2 742/4885 |
| US-20060122225-A1 | Method for producing an optically active tetrahydroquinoline | AADAT, KMO, ALDH7A1 | ALDH1A1 390/4885EPHX2 749/4885TGM2 742/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.