Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 7/20 | 0.53 |
| ▸ | MALT1 | Q9UDY8 | 2/20 | 0.46 |
| ▸ | F13A1 | P00488 | 1/20 | 0.43 |
| ▸ | TGM2 | P21980 | 1/20 | 0.43 |
| ▸ | TGM1 | P22735 | 1/20 | 0.43 |
| ▸ | TGM3 | Q08188 | 1/20 | 0.43 |
| ▸ | KIF18A | Q8NI77 | 4/20 | 0.42 |
| ▸ | SMO | Q99835 | 3/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3219142 | 0.90 | HSD11B1 (0.58) | HSD11B1MALT1KIF18ATRPV1RECQL | |
| SCHEMBL3216059 | 0.84 | HSD11B1 (0.50) | HSD11B1MALT1F13A1TGM2TGM1 | |
| SCHEMBL3209176 | 0.84 | HSD11B1 (0.72) | HSD11B1 | |
| SCHEMBL3210155 | 0.84 | HSD11B1 (0.53) | HSD11B1MALT1KIF18ARECQL | |
| SCHEMBL3221948 | 0.84 | ALDH1A1 (0.55) | HSD11B1MALT1 | |
| SCHEMBL3226054 | 0.82 | HSD11B1 (0.73) | HSD11B1F13A1TGM2TGM1TGM3 | |
| SCHEMBL3210172 | 0.81 | HSD11B1 (0.51) | HSD11B1F13A1TGM2TGM1TGM3 | |
| SCHEMBL3201988 | 0.80 | MALT1 (0.46) | HSD11B1MALT1 | |
| SCHEMBL3221937 | 0.77 | HSD11B1 (0.51) | HSD11B1MALT1KIF18ATRPV1 | |
| SCHEMBL3209933 | 0.77 | HSD11B1 (0.54) | HSD11B1MALT1TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100029648-A1 | 11-Beta HSD1 Inhibitors | XIANG JASON SHAOYUN | 2010-02-04 | — | — | US | disclosed |
| US-7632838-B2 | 11-beta HSD1 inhibitors | WYETH (US) | 2009-12-15 | — | — | US | disclosed |
| US-20070219198-A1 | 11-Beta HSD 1 inhibitors | WYETH (US) | 2007-09-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029648-A1 | 11-Beta HSD1 Inhibitors | HSD11B1, HSD3B1, HSD11B2 | HSD11B1 1/4885MALT1 556/4885F13A1 3898/4885 |
| US-20070219198-A1 | 11-Beta HSD 1 inhibitors | HSD11B1, HSD11B2, HSD3B1 | HSD11B1 1/4885MALT1 593/4885F13A1 3856/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.