Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 3/20 | 0.54 |
| ▸ | MALT1 | Q9UDY8 | 8/20 | 0.49 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.49 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.44 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3215027 | 0.88 | KCNH2 (0.49) | HSD11B1MALT1NFE2L2 | |
| SCHEMBL3219142 | 0.88 | HSD11B1 (0.58) | HSD11B1MALT1TRPV1 | |
| SCHEMBL3216598 | 0.87 | TRPV1 (0.61) | HSD11B1MALT1TRPA1TRPV1 | |
| SCHEMBL3214389 | 0.86 | MALT1 (0.56) | HSD11B1MALT1TRPA1NFE2L2 | |
| SCHEMBL3221937 | 0.84 | HSD11B1 (0.51) | HSD11B1MALT1TRPV1 | |
| SCHEMBL3220012 | 0.84 | HSD11B1 (0.69) | HSD11B1TRPV1 | |
| SCHEMBL3221162 | 0.83 | CTSS (0.54) | HSD11B1MALT1TRPV1 | |
| SCHEMBL3218488 | 0.81 | HRH4 (0.49) | MALT1 | |
| SCHEMBL3198863 | 0.80 | HSD11B1 (0.81) | HSD11B1TRPA1 | |
| SCHEMBL3209868 | 0.77 | HSD11B1 (0.53) | HSD11B1MALT1TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100029648-A1 | 11-Beta HSD1 Inhibitors | XIANG JASON SHAOYUN | 2010-02-04 | — | — | US | disclosed |
| US-7632838-B2 | 11-beta HSD1 inhibitors | WYETH (US) | 2009-12-15 | — | — | US | disclosed |
| US-20070219198-A1 | 11-Beta HSD 1 inhibitors | WYETH (US) | 2007-09-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029648-A1 | 11-Beta HSD1 Inhibitors | HSD11B1, HSD3B1, HSD11B2 | HSD11B1 1/4885MALT1 556/4885TRPA1 4872/4885 |
| US-20070219198-A1 | 11-Beta HSD 1 inhibitors | HSD11B1, HSD11B2, HSD3B1 | HSD11B1 1/4885MALT1 593/4885TRPA1 4834/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.