Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.46 |
| ▸ | KHK | P50053 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA7 | P43166 | 1/20 | 0.32 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.31 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.31 |
| ▸ | MDM4 | O15151 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.30 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.30 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7868318 | 0.83 | TRPV4 (0.52) | TRPV4CA12CA1CA2CA7 | |
| SCHEMBL809118 | 0.83 | TRPV4 (0.50) | TRPV4KHKCA12CA1CA2 | |
| SCHEMBL809217 | 0.78 | TRPV4 (0.52) | TRPV4CA12CA1CA2CA7 | |
| SCHEMBL29728453 | 0.78 | TRPV4 (0.52) | TRPV4CA12CA1CA2CA7 | |
| SCHEMBL9490015 | 0.78 | TRPV4 (0.56) | TRPV4KHK | |
| Acetonitrile SCHEMBL23071362 | 0.76 | TRPV4 (0.44) | TRPV4CA12CA1CA2CA7 | |
| Cyclopropane SCHEMBL28838233 | 0.76 | TRPV4 (0.44) | TRPV4CA12CA1CA2CA7 | |
| SCHEMBL24070359 | 0.75 | TRPV4 (0.59) | TRPV4KHKKDM4E | |
| SCHEMBL9820984 | 0.74 | TRPV4 (0.36) | TRPV4KDM4EADRB2ADRB1 | |
| SCHEMBL1947934 | 0.73 | TRPV4 (0.58) | TRPV4KHKKDM4EMDM4ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9000162-B2 | 5,8-difluoro-4-(2-(4-(heteroaryloxy)-phenyl)ethylamino)quinazolines and their use as agrochemicals | DOW AGROSCIENCES LLC (US) | 2015-04-07 | — | — | US | disclosed |
| US-20130017950-A1 | 5,8-DIFLUORO-4-(2-(4-(HETEROARYLOXY)-PHENYL)ETHYLAMINO)QUINAZOLINES AND THEIR USE AS AGROCHEMICALS | DOW AGROSCIENCES LLC (US) | 2013-01-17 | — | — | US | disclosed |
| US-8268843-B2 | 5,8-difluoro-4-(2-(4-(heteroaryloxy)-phenyl)ethylamino)quinazolines and their use as agrochemicals | DOW AGROSCIENCES, LLC. (US) | 2012-09-18 | — | — | US | disclosed |
| WO-2010025451-A2 | 5,8-DIFLUORO-4-(2-(4-(HETEROARYLOXY)-PHENYL)ETHYLAMINO)QUINAZOLINES AND THEIR USE AS AGROCHEMICALS | DOW AGROSCIENCES LLC (US) | 2010-03-04 | — | — | WO | disclosed |
| US-20100056374-A1 | 5,8-DIFLUORO-4-(2-(4-(HETEROARYLOXY)-PHENYL)ETHYLAMINO)QUINAZOLINES AND THEIR USE AS AGROCHEMICALS | DOW AGROSCIENCES LLC (US) | 2010-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130017950-A1 | 5,8-DIFLUORO-4-(2-(4-(HETEROARYLOXY)-PHENYL)ETHYLAMINO)QUINAZOLINES AND THEIR USE AS AGROCHEMICALS | NQO2, DDT, RAB7A | TRPV4 3237/4885KHK 1242/4885CA12 4556/4885 |
| US-20100056374-A1 | 5,8-DIFLUORO-4-(2-(4-(HETEROARYLOXY)-PHENYL)ETHYLAMINO)QUINAZOLINES AND THEIR USE AS AGROCHEMICALS | NQO2, DDT, RAB7A | TRPV4 3237/4885KHK 1242/4885CA12 4556/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.