Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCOLN3 | Q8TDD5 | 3/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.58 |
| ▸ | PKM | P14618 | 7/20 | 0.58 |
| ▸ | PKLR | P30613 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 4/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18134604 | 0.82 | MCOLN3 (0.83) | MCOLN3TSHRPKMPKLRMEN1 | |
| SCHEMBL23051855 | 0.82 | SMN1; SMN2 (0.71) | MCOLN3TSHRPKMPKLRMEN1 | |
| SCHEMBL3212035 | 0.82 | CTDSP1 (0.62) | MCOLN3TSHRPKMPKLRMEN1 | |
| SCHEMBL3213621 | 0.81 | PKM (0.71) | MCOLN3TSHRPKMPKLRMEN1 | |
| SCHEMBL2950531 | 0.79 | LMNA (0.71) | MCOLN3TSHRPKMMEN1KMT2A | |
| SCHEMBL3222852 | 0.79 | HSD11B1 (0.74) | MCOLN3TSHRPKMPKLRMEN1 | |
| SCHEMBL2961007 | 0.79 | SMN1; SMN2 (0.80) | TSHRPKMMEN1KMT2ALMNA | |
| SCHEMBL3223609 | 0.78 | CHRM4 (0.57) | TSHRKMT2AHSD11B1LMNAMAPT | |
| SCHEMBL3210941 | 0.78 | HSD11B1 (0.72) | MCOLN3TSHRPKMMEN1KMT2A | |
| SCHEMBL3215041 | 0.77 | PKM (0.65) | MCOLN3TSHRPKMPKLRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100029648-A1 | 11-Beta HSD1 Inhibitors | XIANG JASON SHAOYUN | 2010-02-04 | — | — | US | disclosed |
| US-7632838-B2 | 11-beta HSD1 inhibitors | WYETH (US) | 2009-12-15 | — | — | US | disclosed |
| EP-1981848-A2 | 11-BETA HSD1 INHIBITORS | Wyeth (US) | 2008-10-22 | — | — | EP | disclosed |
| US-20070219198-A1 | 11-Beta HSD 1 inhibitors | WYETH (US) | 2007-09-20 | — | — | US | disclosed |
| WO-2007092435-A2 | 11-BETA HSD1 INHIBITORS | WYETH (US) | 2007-08-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029648-A1 | 11-Beta HSD1 Inhibitors | HSD11B1, HSD3B1, HSD11B2 | MCOLN3 4442/4885TSHR 3335/4885PKM 2924/4885 |
| US-20070219198-A1 | 11-Beta HSD 1 inhibitors | HSD11B1, HSD11B2, HSD3B1 | MCOLN3 4525/4885TSHR 2942/4885PKM 2798/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.