Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.34 |
| ▸ | MAPT | P10636 | 5/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | ERN1 | O75460 | 1/20 | 0.33 |
| ▸ | TYMP | P19971 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5227411 | 0.76 | MAPT (0.46) | ACHEKDM4EMAPTMEN1KMT2A | |
| SCHEMBL8163370 | 0.73 | MAPT (0.36) | KDM4EMAPTMEN1KMT2AHPGD | |
| SCHEMBL6661757 | 0.72 | LTA4H (0.39) | ACHEKDM4EMAPTMEN1KMT2A | |
| SCHEMBL10848415 | 0.72 | MAPT (0.35) | ACHEKDM4EMAPTMEN1KMT2A | |
| SCHEMBL6744117 | 0.71 | MAPT (0.44) | ACHEKDM4EMAPTMEN1KMT2A | |
| SCHEMBL7135870 | 0.70 | MAPT (0.52) | ACHEKDM4EMAPTMEN1KMT2A | |
| SCHEMBL616338 | 0.69 | DHODH (0.43) | ACHEKDM4EMAPTMEN1KMT2A | |
| SCHEMBL8013535 | 0.68 | LMNA (0.36) | MAPTALDH1A1TYMPCYP2C9CYP1A2 | |
| SCHEMBL8152470 | 0.68 | MAPT (0.41) | ACHEKDM4EMAPTMEN1KMT2A | |
| SCHEMBL435178 | 0.67 | NOTUM (0.33) | KDM4EMAPTMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7683082-B2 | 3-(5-p-tolyl-[1,2,4]oxadiazol-3-yl)-benzoic acid; translation of mRNA is allowed to continue past a nonsense mutation point, resulting in full length protein; genetic disorders; testing whether a compound increases activity of a protein encoded by an mRNA that contains a premature stop codon | PTC THERAPEUTICS, INC. (US) | 2010-03-23 | — | — | US | disclosed |