Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 14/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 12/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 6/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | KDM1A | O60341 | 1/20 | 0.52 |
| ▸ | MAOB | P27338 | 1/20 | 0.52 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4229238 | 0.75 | GABRD (0.71) | CYP3A4CYP2D6CYP2C19ALDH1A1CYP2C9 | |
| SCHEMBL23774536 | 0.74 | KDM1A (0.50) | HPGDCYP3A4CYP2D6CYP2C19ALDH1A1 | |
| SCHEMBL3211666 | 0.72 | HSD11B1 (0.55) | HPGDCYP3A4CYP2D6CYP2C19ALDH1A1 | |
| SCHEMBL13050668 | 0.70 | HPGD (1.00) | HPGDCYP3A4CYP2D6CYP2C19ALDH1A1 | |
| SCHEMBL3800396 | 0.69 | KMT2A (0.50) | CYP3A4CYP2D6ALDH1A1KMT2A | |
| SCHEMBL939303 | 0.68 | CYP3A4 (0.82) | HPGDCYP3A4CYP2D6CYP2C19ALDH1A1 | |
| Hydrochloric Acid SCHEMBL7008715 | 0.67 | CYP3A4 (0.80) | HPGDCYP3A4CYP2D6CYP2C19ALDH1A1 | |
| Hydrochloric Acid SCHEMBL484648 | 0.67 | CYP3A4 (0.80) | HPGDCYP3A4CYP2D6CYP2C19ALDH1A1 | |
| SCHEMBL19159945 | 0.66 | CYP3A4 (0.68) | HPGDCYP3A4CYP2D6CYP2C19ALDH1A1 | |
| SCHEMBL19992731 | 0.65 | TSHR (0.58) | CYP3A4CYP2D6CYP2C19ALDH1A1KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100234340-A1 | Substituted Spiroamide Compounds | GRUENENTHAL GMBH (DE) | 2010-09-16 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100234340-A1 | Substituted Spiroamide Compounds | BDKRB1, BDKRB2, AVPR1B | HPGD 1004/4885CYP3A4 1215/4885CYP2D6 950/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.