Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 3/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 8/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.49 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | FNTA | P49354 | 1/20 | 0.45 |
| ▸ | FNTB | P49356 | 1/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5428790 | 0.80 | ALDH1A1 (0.47) | HSD11B1HPGDCYP2D6CYP3A4CYP2C19 | |
| SCHEMBL293023 | 0.79 | FNTA (0.57) | HSD11B1HPGDCYP2D6CYP3A4ALDH1A1 | |
| SCHEMBL19137834 | 0.78 | OPRM1 (0.67) | HSD11B1CYP2D6CYP3A4ITGB3ITGA2B | |
| SCHEMBL19137835 | 0.78 | OPRM1 (0.67) | HSD11B1CYP2D6CYP3A4ITGB3ITGA2B | |
| SCHEMBL4229238 | 0.76 | GABRD (0.71) | CYP2D6CYP3A4CYP2C19ALDH1A1CYP2C9 | |
| SCHEMBL3211663 | 0.72 | HPGD (0.53) | HPGDCYP2D6CYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL8118154 | 0.71 | SMN1; SMN2 (0.65) | HPGDCYP3A4ALDH1A1CYP1A2MEN1 | |
| SCHEMBL13050668 | 0.71 | HPGD (1.00) | HPGDCYP2D6CYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL19159945 | 0.70 | CYP3A4 (0.68) | HPGDCYP2D6CYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL25931529 | 0.70 | CYP1A2 (0.44) | HSD11B1CYP2D6CYP3A4CYP1A2KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100234340-A1 | Substituted Spiroamide Compounds | GRUENENTHAL GMBH (DE) | 2010-09-16 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100234340-A1 | Substituted Spiroamide Compounds | BDKRB1, BDKRB2, AVPR1B | HSD11B1 1346/4885HPGD 1004/4885CYP2D6 950/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.